https://orcid.org/0000-0002-8115-8592
Figures & data
Figure 1. Iron chelation with deferiprone leads to reduced protein levels of the ubiquitin ligase STUB1/CHIP, which promotes degradation of the deSUMOylating enzyme SENP3. Reduced STUB1/CHIP levels lead to stabilization of SENP3, favoring deSUMOylation of its substrate FIS1. FIS1 deSUMOylation leads to an enhancement of FIS1 localization at the outer mitochondrial membrane, permitting the induction of mitophagy.
