Autophagy, Volume 18, Issue 7 (2022)

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Autophagy, Volume 18, Issue 7 (2022)

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Editor’s Corner

Editorial
CCT2, a newly identified aggrephagy receptor in mammals, specifically mediates the autophagic clearance of solid protein aggregates
Zhihai Zhang & Daniel J. Klionsky
Pages: 1483-1485
Published online: 14 Jun 2022
AbstractforCCT2, a newly identified aggrephagy receptor in mammals, specifically mediates the autophagic clearance of solid protein aggregates | Full Text | References | PDF (213.6 KB) | EPUB
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Research paper

Article
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy
Tatiana A. Giovannucci, Florian A. Salomons, Henriette Stoy, Laura K. Herzog, Shanshan Xu, Weixing Qian, Lara G. Merino, Maria E. Gierisch, Martin Haraldsson, Alf H. Lystad, Hanna Uvell, Anne Simonsen, Anna-Lena Gustavsson, Michaela Vallin & Nico P. Dantuma
Pages: 1486-1502
Published online: 05 Nov 2021
AbstractforIdentification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 3595 Views
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Open Access
Article
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells
Yabin Gong, Ning Tang, Panrao Liu, Yingjie Sun, Shanxin Lu, Weiwei Liu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Shengqing Yu, Xiufan Liu, Shu-Hai Lin & Chan Ding
Pages: 1503-1521
Published online: 31 Oct 2021
AbstractforNewcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
  • 8092 Views
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Brief Report

Brief Report
Degradative tubular lysosomes link pexophagy to starvation and early aging in C. elegans
Dominique A. Dolese, Matthew P. Junot, Bhaswati Ghosh, Tyler J. Butsch, Alyssa E. Johnson & K. Adam Bohnert
Pages: 1522-1533
Published online: 12 Dec 2021
AbstractforDegradative tubular lysosomes link pexophagy to starvation and early aging in C. elegans | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 4306 Views
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Open Access

Research paper

Article
Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5
Hansjörg Schwertz, Jesse W. Rowley, Irina Portier, Elizabeth A. Middleton, Neal D. Tolley, Robert A. Campbell, Alicia S. Eustes, Karin Chen & Matthew T. Rondina
Pages: 1534-1550
Published online: 18 Nov 2021
AbstractforHuman platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5 | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2004 Views
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Article
Lysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes
S. Joseph Endicott, Alexander C. Monovich, Eric L. Huang, Evelynn I. Henry, Dennis N. Boynton, Logan J. Beckmann, Michael J. MacCoss & Richard A. Miller
Pages: 1551-1571
Published online: 29 Dec 2021
AbstractforLysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
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Article
Loss of acinar cell VMP1 triggers spontaneous pancreatitis in mice
Shaogui Wang, Xiaojuan Chao, Xiaoxiao Jiang, Tiantian Wang, Yssa Rodriguez, Ling Yang, Pal Pacher, Hong-Min Ni & Wen-Xing Ding
Pages: 1572-1582
Published online: 28 Oct 2021
AbstractforLoss of acinar cell VMP1 triggers spontaneous pancreatitis in mice | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2670 Views
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Article
A noncanonical autophagy is involved in the transfer of Plasmodium-microvesicles to astrocytes
Inès Leleu, Delphine Genete, Sophie Salomé Desnoulez, Nasreddine Saidi, Priscille Brodin, Frank Lafont, Stanislas Tomavo & Sylviane Pied
Pages: 1583-1598
Published online: 06 Nov 2021
AbstractforA noncanonical autophagy is involved in the transfer of Plasmodium-microvesicles to astrocytes | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3332 Views
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Open Access

Research Paper

Article
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress
Jia-min Yan, Wen-kang Zhang, Li-na Yan, Yong-Jun Jiao, Chuan-min Zhou & Xue-jie Yu
Pages: 1599-1612
Published online: 06 Nov 2021
AbstractforBunyavirus SFTSV exploits autophagic flux for viral assembly and egress | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 7721 Views
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Research paper

Article
SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores
Jee-Eun Lee, Nari Kim, Minkyo Jung, Ji-Young Mun & Joo-Yeon Yoo
Pages: 1613-1628
Published online: 31 Oct 2021
AbstractforSHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
  • 1515 Views
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Article
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization
Tsutomu Tanaka, Blake M. Warner, Drew G. Michael, Hiroyuki Nakamura, Toshio Odani, Hongen Yin, Tatsuya Atsumi, Masayuki Noguchi & John A. Chiorini
Pages: 1629-1647
Published online: 22 Nov 2021
AbstractforLAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 5452 Views
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Article
An exploratory text analysis of the autophagy research field
Willa Wen-You Yim, Yoshitaka Kurikawa & Noboru Mizushima
Pages: 1648-1661
Published online: 23 Nov 2021
AbstractforAn exploratory text analysis of the autophagy research field | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1016 Views
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Brief Report

Brief Report
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males
Susanna Croci, Mary Anna Venneri, Stefania Mantovani, Chiara Fallerini, Elisa Benetti, Nicola Picchiotti, Federica Campolo, Francesco Imperatore, Maria Palmieri, Sergio Daga, Chiara Gabbi, Francesca Montagnani, Giada Beligni, Ticiana D.J. Farias, Miriam Lucia Carriero, Laura Di Sarno, Diana Alaverdian, Sigrid Aslaksen, Maria Vittoria Cubellis, Ottavia Spiga, Margherita Baldassarri, Francesca Fava, Paul J. Norman, Elisa Frullanti, Andrea M. Isidori, Antonio Amoroso, Francesca Mari, Simone Furini, Mario U Mondelli, GEN-COVID multicenter study, Mario Chiariello, Alessandra Renieri & Ilaria Meloni
Pages: 1662-1672
Published online: 29 Dec 2021
AbstractforThe polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 3019 Views
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Open Access

Research Paper

Article
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation
Dongsheng Bai, Jiaying Du, Xiumin Bu, Wangjia Cao, Tifan Sun, Jiawei Zhao, Yue Zhao & Na Lu
Pages: 1673-1693
Published online: 25 Nov 2021
AbstractforALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
  • 5430 Views
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Article
Post-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses
Vikramjit Lahiri, Shree Padma Metur, Zehan Hu, Xinxin Song, Muriel Mari, Wayne D. Hawkins, Janakraj Bhattarai, Elizabeth Delorme-Axford, Fulvio Reggiori, Daolin Tang, Joern Dengjel & Daniel J. Klionsky
Pages: 1694-1714
Published online: 26 Nov 2021
AbstractforPost-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1548 Views
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Research paper

Article
Quantitative retrospective natural history modeling of WDR45-related developmental and epileptic encephalopathy – a systematic cross-sectional analysis of 160 published cases
Afshin Saffari, Julian Schröter, Sven F. Garbade, Julian E. Alecu, Darius Ebrahimi-Fakhari, Georg F. Hoffmann, Stefan Kölker, Markus Ries & Steffen Syrbe
Pages: 1715-1727
Published online: 24 Nov 2021
AbstractforQuantitative retrospective natural history modeling of WDR45-related developmental and epileptic encephalopathy – a systematic cross-sectional analysis of 160 published cases | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 1079 Views
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Commentary and Views

Article
The role of autophagy in the pathogenesis of SARS-CoV-2 infection in different cell types
Nastaran Samimi, Mojtaba Farjam, Daniel J. Klionsky & Nima Rezaei
Pages: 1728-1731
Published online: 28 Oct 2021
First Page PreviewforThe role of autophagy in the pathogenesis of SARS-CoV-2 infection in different cell types | Full Text | References | PDF (777.5 KB) | EPUB
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Autophagic Punctum

Article Commentary
Developmentally regulated selective autophagy determines ER inheritance by gametes
George Maxwell Otto & Gloria Ann Brar
Pages: 1732-1733
Published online: 27 Feb 2022
AbstractforDevelopmentally regulated selective autophagy determines ER inheritance by gametes | Full Text | References | PDF (980 KB) | EPUB
  • 445 Views
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Article Commentary
Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia
Angela Ianniciello & G. Vignir Helgason
Pages: 1734-1736
Published online: 01 Mar 2022
AbstractforTargeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia | Full Text | References | PDF (425.7 KB) | EPUB
  • 674 Views
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Article Commentary
Susceptibility to autophagy inhibition is enhanced by dual IGF1R and MAPK/ERK inhibition in pancreatic cancer
Clint A. Stalnecker, Michael F. Coleman & Kirsten L. Bryant
Pages: 1737-1739
Published online: 24 Feb 2022
AbstractforSusceptibility to autophagy inhibition is enhanced by dual IGF1R and MAPK/ERK inhibition in pancreatic cancer | Full Text | References | PDF (569.2 KB) | EPUB
  • 972 Views
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Article Commentary
Celastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease
Wei Zhang, Jigang Wang & Chuanbin Yang
Pages: 1740-1742
Published online: 06 Mar 2022
AbstractforCelastrol, a TFEB (transcription factor EB) agonist, is a promising drug candidate for Alzheimer disease | Full Text | References | PDF (482 KB) | EPUB
  • 1786 Views
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Article Commentary
Iron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1
Kevin A. Wilkinson & Chun Guo
Pages: 1743-1745
Published online: 11 Mar 2022
AbstractforIron chelation promotes mitophagy through SENP3-mediated deSUMOylation of FIS1 | Full Text | References | PDF (357.3 KB) | EPUB
  • 3230 Views
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Open Access
Article Commentary
Transmembrane protein ATG-9 links presynaptic autophagy with the synaptic vesicle cycle
Sisi Yang & Daniel A. Colón-Ramos
Pages: 1746-1747
Published online: 29 Mar 2022
AbstractforTransmembrane protein ATG-9 links presynaptic autophagy with the synaptic vesicle cycle | Full Text | References | PDF (969.3 KB) | EPUB
  • 1988 Views
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