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Autophagy Volume 19, 2023 - Issue 1
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Autophagic Punctum

N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancer

Hui Hana Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaORCID Iconhttps://orcid.org/0000-0003-0357-4651View further author information
ORCID Icon,
Siyi Zhenga Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaView further author information
&
Shuibin Lina Department of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;b State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7065-614XView further author information
ORCID Icon
Pages 360-362 | Received 27 Apr 2022, Accepted 09 May 2022, Published online: 23 May 2022

Figures & data

Figure 1. Mechanism of translational machinery in regulating autophagic machinery. METTL1-mediated m7G tRNA modification enhances the translation of MTORC1 components in an m7G-related codon-dependent manner to phosphorylates and inactivates ULK1, thus blocking hyperactivation of autophagy.

Figure 1. Mechanism of translational machinery in regulating autophagic machinery. METTL1-mediated m7G tRNA modification enhances the translation of MTORC1 components in an m7G-related codon-dependent manner to phosphorylates and inactivates ULK1, thus blocking hyperactivation of autophagy.

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