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Autophagy Volume 19, 2023 - Issue 1
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Autophagic Punctum

The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy

Panpan Houa MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Tian Tianb Center for Applied Genomics, Children’s Hospital of Philadelphia, Philadelphia, PA, USAView further author information
,
Penghui Jiaa MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Yuxin Lina MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Zibo Lia MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Yicheng Wanga MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Yu Yea MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
,
Chunmei Lia MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaView further author information
&
Deyin Guoa MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study (CIIS), School of Medicine, Sun Yat-sen University, Shenzhen, ChinaCorrespondence[email protected]
View further author information
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Pages 365-366 | Received 26 Apr 2022, Accepted 18 May 2022, Published online: 27 May 2022

Figures & data

Figure 1. The schematic diagram of a working model of CCDC50 in the regulation of NLRP3 inflammasome activation. Upon PAMPs or DAMPs stimulation, the NLRP3 inflammasome assembly is initiated to assist host cells fight against microbial infection or monitor cellular damage. In the meantime, the autophagy cargo receptor CCDC50 is induced and then CCDC50 targets K63-polyubiqutinated NLRP3 for autophagic degradation, consequently disrupting NLRP3 oligomerization and further inhibiting NLRP3 inflammasome assembly. Ubn, polyubiquitin.

Figure 1. The schematic diagram of a working model of CCDC50 in the regulation of NLRP3 inflammasome activation. Upon PAMPs or DAMPs stimulation, the NLRP3 inflammasome assembly is initiated to assist host cells fight against microbial infection or monitor cellular damage. In the meantime, the autophagy cargo receptor CCDC50 is induced and then CCDC50 targets K63-polyubiqutinated NLRP3 for autophagic degradation, consequently disrupting NLRP3 oligomerization and further inhibiting NLRP3 inflammasome assembly. Ubn, polyubiquitin.

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