Figures & data
Figure 1. Following mitochondrial damage, TRIM5 localizes to ER-mitochondrial contact sites where it recruits the autophagy initiation machinery, including ULK1 complex proteins, to proteins tagging damaged mitochondria (eat-me tags). In the absence of TRIM5, the recruitment of autophagy proteins to damaged mitochondria is abrogated, mitophagy is impaired, and cells show elevated inflammatory responses to mitochondrial damage. Abbreviations: ER, endoplasmic reticulum; PG, phagophore. Figure was created using BioRender.
