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Epigenetics Volume 15, 2020 - Issue 6-7
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Research Paper

4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation

Xiaonan Shia Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, China;c Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaView further author information
,
Libao Gonga Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Yunpeng Liua Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Kezuo Houa Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Yibo Fana Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Ce Lia Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Ti Wena Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaView further author information
,
Xiujuan Qua Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaCorrespondence[email protected]
View further author information
&
Xiaofang Chea Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China;b Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9087-1007View further author information
ORCID Icon show all
Pages 632-645 | Received 16 Jul 2019, Accepted 22 Nov 2019, Published online: 09 Dec 2019

Figures & data

Figure 1. 4-PBA induced gastric cancer cells EMT with aberrant E-cadherin expression.

Figure 1. 4-PBA induced gastric cancer cells EMT with aberrant E-cadherin expression.

Figure 2. 4-PBA-induced EMT by IL-8 upregulation in gastric cancer cells.

Figure 2. 4-PBA-induced EMT by IL-8 upregulation in gastric cancer cells.

Figure 3. 4-PBA-upregulated IL-8 induced EMT through ERK signalling pathway in gastric cancer cells.

Figure 3. 4-PBA-upregulated IL-8 induced EMT through ERK signalling pathway in gastric cancer cells.

Figure 4. Gab2 phosphorylation mediated IL-8-induced ERK activation.

Figure 4. Gab2 phosphorylation mediated IL-8-induced ERK activation.

Figure 5. 4-PBA upregulated IL-8 expression and IL-8 pathway activation through HDAC activity inhibition.

Figure 5. 4-PBA upregulated IL-8 expression and IL-8 pathway activation through HDAC activity inhibition.

Figure 6. Schematic representation of the proposed model.

Figure 6. Schematic representation of the proposed model.

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