4-phenylbutyric acid promotes migration of gastric cancer cells by histone deacetylase inhibition-mediated IL-8 upregulation

References

• Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012 Jul 6;150(1):12–27. PubMed PMID: 22770212; eng.
   PubMed Web of Science ®Google Scholar
• Menzies KJ, Zhang H, Katsyuba E, et al. Protein acetylation in metabolism – metabolites and cofactors. Nat Rev Endocrinol. 2016 Jan;12(1):43–60. PubMed PMID: 26503676; eng.
   PubMed Web of Science ®Google Scholar
• Weichert W, Denkert C, Noske A, et al. Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas. Neoplasia (New York, NY). 2008 Sep;10(9):1021–1027. PubMed PMID: 18714364; PubMed Central PMCID: PMCPmc2517648. eng.
   PubMed Web of Science ®Google Scholar
• Weichert W, Roske A, Gekeler V, et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol. 2008 Feb;9(2):139–148. PubMed PMID: 18207460; eng.
   PubMed Web of Science ®Google Scholar
• Jia D, Augert A, Kim DW, et al. Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition. Cancer Discov. 2018 Nov;8(11):1422–1437. PubMed PMID: 30181244; PubMed Central PMCID: PMCPmc6294438. eng.
   PubMed Web of Science ®Google Scholar
• Mottamal M, Zheng S, Huang TL, et al. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents. Molecules. 2015 Mar 2;20(3):3898–3941. PubMed PMID: 25738536; PubMed Central PMCID: PMCPmc4372801. eng.
   PubMed Web of Science ®Google Scholar
• Iwamoto M, Friedman EJ, Sandhu P, et al. Clinical pharmacology profile of vorinostat, a histone deacetylase inhibitor. Cancer Chemother Pharmacol. 2013 Sep;72(3):493–508. PubMed PMID: 23820962; eng.
   PubMed Web of Science ®Google Scholar
• Carducci MA, Gilbert J, Bowling MK, et al. A phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. Clin Cancer Res off J Am Assoc cancer res. 2001 Oct;7(10):3047–3055. PubMed PMID: 11595694; eng.
   PubMed Web of Science ®Google Scholar
• Lin J, Gilbert J, Rudek MA, et al. A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors. Clin Cancer Res off J Am Assoc cancer res. 2009 Oct 1;15(19):6241–6249. 10.1158/1078-0432.ccr-09-0567. PubMed PMID: 19789320; PubMed Central PMCID: PMCPmc2845396. eng.
   PubMed Web of Science ®Google Scholar
• Maslak P, Chanel S, Camacho LH, et al. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Leukemia. 2006 Feb;20(2):212–217. PubMed PMID: 16357841; eng.
   PubMed Web of Science ®Google Scholar
• Camacho LH, Olson J, Tong WP, et al. Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors. Invest New Drugs. 2007 Apr;25(2):131–138. PubMed PMID: 17053987; eng.
   PubMed Web of Science ®Google Scholar
• McAuley EM, Bradke TA, Plopper GE. Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration. Cell Adh Migr. 2011 September–-October;5(5):382–386. PubMed PMID: 21975546; PubMed Central PMCID: PMCPmc3218604. eng.
   PubMed Web of Science ®Google Scholar
• Lv LV, Zhou J, Lin C, et al. DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells. Oncol Lett. 2015 Aug;10(2):907–912. PubMed PMID: 26622593; PubMed Central PMCID: PMCPmc4509424. eng.
   PubMed Web of Science ®Google Scholar
• Wu L, Feng H, Hu J, et al. Valproic acid (VPA) promotes the epithelial mesenchymal transition of hepatocarcinoma cells via transcriptional and post-transcriptional up regulation of snail. Biomed Pharmacothe. 2016 Dec;84:1029–1035. PubMed PMID: 27768928; eng.
   PubMed Web of Science ®Google Scholar
• Wang JH, Lee EJ, Ji M, et al. HDAC inhibitors, trichostatin A and valproic acid, increase ecadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. Oncol Rep. 2018 Jul;40(1):346–354. PubMed PMID: 29767267; eng.
   PubMed Web of Science ®Google Scholar
• Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009 Jun;28(1–2):15–33. PubMed PMID: 19169796; eng.
   PubMed Web of Science ®Google Scholar
• Huang RY, Guilford P, Thiery JP. Early events in cell adhesion and polarity during epithelial-mesenchymal transition. J Cell Sci. 2012 Oct 1;125(Pt 19):4417–4422. PubMed PMID: 23165231; eng.
   PubMed Web of Science ®Google Scholar
• Neel BG, Gu H, Pao L. The ‘Shp’ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci. 2003 Jun;28(6):284–293. PubMed PMID: 12826400; eng.
   PubMed Web of Science ®Google Scholar
• Gu H, Pratt JC, Burakoff SJ, et al. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 1998 Dec;2(6):729–740. PubMed PMID: 9885561; eng.
   PubMed Web of Science ®Google Scholar
• Tang HM, Kuay KT, Koh PF, et al. An epithelial marker promoter induction screen identifies histone deacetylase inhibitors to restore epithelial differentiation and abolishes anchorage independence growth in cancers. Cell Death Discov. 2016;2:16041. PubMed PMID: 27551531; PubMed Central PMCID: PMCPmc4979427. eng.
   PubMed Web of Science ®Google Scholar
• Ying R, Wang XQ, Yang Y, et al. Hydrogen sulfide suppresses endoplasmic reticulum stress-induced endothelial-to-mesenchymal transition through Src pathway. Life Sci. 2016 Jan;1(144):208–217. PubMed PMID: 26656263; eng.
   PubMed Web of Science ®Google Scholar
• Han RF, Li K, Yang ZS, et al. Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. Mol Med Rep. 2014 Dec;10(6):3211–3216. PubMed PMID: 25269990; eng.
   PubMed Web of Science ®Google Scholar
• Guzman P, Araya J, Villaseca M, et al. Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer. Revista Medica de Chile. 2006 Aug;134(8):1002–1009. PubMed PMID: 17130988; spa.
   PubMed Web of Science ®Google Scholar
• Gallagher EM, O’Shea DM, Fitzpatrick P, et al. Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization. Clin Cancer Res off J Am Assoc cancer res. 2008 Nov 1;14(21):6829–6838. PubMed PMID: 18980977; eng.
   PubMed Web of Science ®Google Scholar
• Jordaan G, Liao W, Sharma S. E-cadherin gene re-expression in chronic lymphocytic leukemia cells by HDAC inhibitors. BMC Cancer. 2013 Feb 25;13:88. PubMed PMID: 23432814; PubMed Central PMCID: PMCPmc3586366. eng.
   PubMed Web of Science ®Google Scholar
• Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res off J Am Assoc cancer res. 2008 Nov 1;14(21):6735–6741. PubMed PMID: 18980965; eng.
   PubMed Web of Science ®Google Scholar
• Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001 Feb 17;357(9255):539–545. PubMed PMID: 11229684; eng.
   PubMed Web of Science ®Google Scholar
• Holmes WE, Lee J, Kuang WJ, et al. Structure and functional expression of a human interleukin-8 receptor. Science (New York, NY). 1991 Sep 13;253(5025):1278–1280. PubMed PMID: 1840701; eng.
   Google Scholar
• Araki S, Omori Y, Lyn D, et al. Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Cancer Res. 2007 Jul 15;67(14):6854–6862. PubMed PMID: 17638896; eng.
   PubMed Web of Science ®Google Scholar
• Vancurova I, Uddin MM, Zou Y, et al. Combination therapies targeting HDAC and IKK in solid tumors. Trends Pharmacol Sci. 2018 Mar;39(3):295–306. PubMed PMID: 29233541; PubMed Central PMCID: PMCPmc5818305. eng.
   PubMed Web of Science ®Google Scholar
• Adam E, Quivy V, Bex F, et al. Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol. 2003 Sep;23(17):6200–6209. PubMed PMID: 12917341; PubMed Central PMCID: PMCPmc180966. eng.
   PubMed Web of Science ®Google Scholar
• Chavey C, Muhlbauer M, Bossard C, et al. Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer. Mol Pharmacol. 2008 Nov;74(5):1359–1366. PubMed PMID: 18669446; eng.
   PubMed Web of Science ®Google Scholar
• Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005 Apr;7(2):122–133. PubMed PMID: 15831231; PubMed Central PMCID: PMCPmc1871893. eng.
   PubMed Web of Science ®Google Scholar
• Cheng XS, Li YF, Tan J, et al. CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition. Cancer Lett. 2014 Jun 28;348(1–2):77–87. PubMed PMID: 24657657; eng.
   PubMed Web of Science ®Google Scholar
• Hwang WL, Yang MH, Tsai ML, et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology. 2011 Jul;141(1):279–91, 291.e1–5. PubMed PMID: 21640118; eng.
   PubMed Web of Science ®Google Scholar
• Visciano C, Liotti F, Prevete N, et al. Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway. Oncogene. 2015 Oct 1;34(40):5175–5186. PubMed PMID: 25619830; eng.
   PubMed Web of Science ®Google Scholar
• Ding CB, Yu WN, Feng JH, et al. Structure and function of Gab2 and its role in cancer (Review). Mol Med Rep. 2015 Sep;12(3):4007–4014. PubMed PMID: 26095858; PubMed Central PMCID: PMCPmc4526075. eng.
   PubMed Web of Science ®Google Scholar
• Li H, Xu L, Zhao L, et al. Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line. Oncol Lett. 2015 Jan;9(1):143–148. PubMed PMID: 25435948; PubMed Central PMCID: PMCPmc4246767. eng.
   PubMed Web of Science ®Google Scholar