Prevalence of G6PD deficiency in Thai blood donors, the characteristics of G6PD deficient blood, and the efficacy of fluorescent spot test to screen for G6PD deficiency in a hospital blood bank setting

Figures & data

Table 1. Demographic data, types of blood products, and red blood cell (RBC) parameters compared between the normal control group and the glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency group.

Characteristic and test	G6PD normal (n = 10)	G6PD deficiency (n = 39)	P value
Male, n (%)	10 (100)	35 (89.7)	–
Donor age (range)	33.9 (21-54)	34.2 (18-58)
Blood product
AS-RBC	2	3	–
LPB	7	29	–
PFB	1	7	–
RBC indices
Hb (mean ± SD) (g/dL)	18.7 ± 1.4	18.3 ± 1.1	0.369
Hematocrit (%)	56.5 ± 4.0	57.5 ± 3.4	0.107
MCV (median and IQR) (fL)	85.9 (76.2-91.7)**	90.5 (85.3-93.9)**	0.099
MCH (pg)	27.2 ± 4.1	29.2 (27.3-30.2)**	0.682
MCHC (g/dL)	33.1 ± 1.0	31.9 ± 1.1	0.009*
RBC (x10^12/L)	6.99 ± 0.96	6.5 ± 0.69	0.132
RDW (%)	15.7 ± 2.8	12.8 (12.4-14.0)**	0.006*

Independent Sample T-Test and Mann-Whitney-U were used to compare means and medians in the normal and skewed distribution data, respectively.*p value <0.05 is considered significant **data that are not in the normal distribution. AS-RBC - red cells in additive solution, LPB – leukocyte poor blood, PFB – prestorage filtered blood, RBC – red blood cells, Hb – hemoglobin, MCV – mean corpuscular volume, MCH – mean corpuscular hemoglobin, MCHC – mean corpuscular hemoglobin concentration, RDW – red cell distribution width

Figure 1. Rate of hemolysis in all types of red blood cell (RBC) products compared between the normal control group and the glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency group at day 1, day 7, day 14, day 21, and day 35 of storage. Hemolysis were significantly higher (*p <0.05) in the normal control group on day 7 and day 35. Mann-Whitney U test was applied for this comparison. The bars within the chart reflect the median, and the error bars represent the interquartile range.