Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia

Figures & data

Figure 1. Structure of NPM1. NPM1 is composed of an N-terminal oligomerization domain (NTD), a central region, and a C-terminal DNA/RNA binding domain (CTD). NTD contains two nuclear export signals (NES) and one metal binding domain (MBD), function as protein chaperone. The central region harbors two acidic domains (AD) and one nuclear localization signal (NLS), NPM1 binds histones via mimic DNA/RNA through its ADs. The CTD consists of another NLS, one moderately basic region (MBR), one basic cluster (BC), one aromatic region (AR), and one nucleolar localization signal (NoLS).