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Research Article

Frequency and clinical impact of WT1 mutations in the context of CEBPA-mutated acute myeloid leukemia

Ting Wanga Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaView further author information

Haiying Huab Department of Hematology, Wuxi Third people’s hospital, Wuxi, People’s Republic of ChinaView further author information

Zheng Wangc National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, People’s Republic of China;d Suzhou jsuniwell medical laboratory, Suzhou, People’s Republic of ChinaView further author information

Biao Wange Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of ChinaView further author information

Liujun Caof Department of Hematology, Affiliated Jintan People’s Hospital of Jiangsu University, Changzhou, People’s Republic of ChinaView further author information

Wei Qina Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaView further author information

Pin Wug Department of Hematology, Wuxi Second people’s hospital, Wuxi, People’s Republic of ChinaView further author information

Xiaohui Caia Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaView further author information

Hongying Chaoa Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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XuZhang Lua Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Figures & data

Table 1. Pretreatment clinical characteristics according to CEBPA mutation status.

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Figure 1. Schematic showing the locations of WT1 mutations found in CEBPA mutated AML. One patient had both the R380G and S381fs mutations.

Table 2. WT1. mutations information in 29 patients with CEBPA^mut AML.

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Figure 2. Spectrum of acquired co-mutations in 29WT1 mutated patients with CEBPA mutated AML divided into different mutational categories. Each bar represents a distinct driver gene.

Table 3. Concomitant gene abnormalities according to WT1 mutation status.

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Figure 3. Influence of mutations in WT1on survival. a. Kaplan–Meier estimates of Relapse-free survival (RFS), b.event-free survival (EFS) and c. overall survival (OS) in newly diagnosed patients with CEBPAdouble mutated AML, according to the presence or absence of mutations in WT1.

Table 4. Univariable outcome analyses according to WT1 mutation status.

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Frequency and clinical impact of WT1 mutations in the context of CEBPA-mutated acute myeloid leukemia

Table 1. Pretreatment clinical characteristics according to CEBPA mutation status.

Table 2. WT1. mutations information in 29 patients with CEBPA^mut AML.

Table 3. Concomitant gene abnormalities according to WT1 mutation status.

Table 4. Univariable outcome analyses according to WT1 mutation status.

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Frequency and clinical impact of WT1 mutations in the context of CEBPA-mutated acute myeloid leukemia

Figures & data

Table 1. Pretreatment clinical characteristics according to CEBPA mutation status.

Table 2. WT1. mutations information in 29 patients with CEBPAmut AML.

Table 3. Concomitant gene abnormalities according to WT1 mutation status.

Table 4. Univariable outcome analyses according to WT1 mutation status.

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Table 2. WT1. mutations information in 29 patients with CEBPA^mut AML.