A new route for the synthesis of functionalized benzothiadiazine 1,1-dioxide derivatives via intramolecular C–H activation reactions of N,N′,N′′-trisubstituted guanidines and benzenesulfonylchloride

ABSTRACT

In this study, a simple and appropriate procedure for the synthesis of functionalized benzothiadiazine 1,1-dioxide with good yields via the Cu-catalyzed intramolecular C–H activation reaction from benzenesulfonylchloride and N,N′,N′′-trisubstitutedguanidines, generated by copper(II) oxide-catalyzed hydroamination of carbodiimides, is reported.

GRAPHICAL ABSTRACT

KEYWORDS:

• C–H activation
• copper-catalyzed
• benzothiadiazine 1,1-dioxide
• benzenesulfonylchloride
• N
• n'-dicyclohexylcarbodiimide
• primary amine

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Research Council of Shahid Beheshti University of Medical Sciences.