4,410
Views
15
CrossRef citations to date
0
Altmetric
Review

Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents

, , , , , , , , , & show all
Pages 1497-1516 | Received 25 Feb 2021, Accepted 14 Jul 2021, Published online: 30 Jul 2021

Figures & data

Figure 1. Structures and cytotoxic effects of ring A modified derivatives 1–11.

Figure 1. Structures and cytotoxic effects of ring A modified derivatives 1–11.

Figure 2. Structures and cytotoxic effects of ring A modified derivatives 12–17.

Figure 2. Structures and cytotoxic effects of ring A modified derivatives 12–17.

Figure 3. Structures and cytotoxic effects of ring A modified derivatives 18–34.

Figure 3. Structures and cytotoxic effects of ring A modified derivatives 18–34.

Figure 4. Structures and cytotoxic effects of ring A modified derivatives 35–43.

Figure 4. Structures and cytotoxic effects of ring A modified derivatives 35–43.

Figure 5. Structures and cytotoxic effects of ring A enones 44–49.

Figure 5. Structures and cytotoxic effects of ring A enones 44–49.

Figure 6. Structures and cytotoxic effects of ring A modified derivatives 50–56.

Figure 6. Structures and cytotoxic effects of ring A modified derivatives 50–56.

Figure 7. Structures and cytotoxic effects of ring A modified derivatives 57–64.

Figure 7. Structures and cytotoxic effects of ring A modified derivatives 57–64.

Figure 8. Structures and cytotoxic effects of C-30 modified ester derivatives 65–67.

Figure 8. Structures and cytotoxic effects of C-30 modified ester derivatives 65–67.

Figure 9. Structures and cytotoxic effects of GA-amino acid coupled derivatives 68–79.

Figure 9. Structures and cytotoxic effects of GA-amino acid coupled derivatives 68–79.

Figure 10. Structures and cytotoxic effects of GA-amino acid coupled derivatives 80–89.

Figure 10. Structures and cytotoxic effects of GA-amino acid coupled derivatives 80–89.

Figure 11. Structures and cytotoxic effects of GA-amino acid coupled derivatives 90–102.

Figure 11. Structures and cytotoxic effects of GA-amino acid coupled derivatives 90–102.

Figure 12. Structures and cytotoxic effects of GA-cinnamic acids coupled derivatives 103–107.

Figure 12. Structures and cytotoxic effects of GA-cinnamic acids coupled derivatives 103–107.

Figure 13. Structures and cytotoxic effects of GA-cinnamic acids coupled derivatives 108–114.

Figure 13. Structures and cytotoxic effects of GA-cinnamic acids coupled derivatives 108–114.

Figure 14. Structures and cytotoxic effects of GA glycosides 115 and 116.

Figure 14. Structures and cytotoxic effects of GA glycosides 115 and 116.

Figure 15. Structures and cytotoxic effects of GA C-3 amino derivatives 117–128.

Figure 15. Structures and cytotoxic effects of GA C-3 amino derivatives 117–128.

Figure 16. Structures and cytotoxic effects of GA C-3 amino derivatives 129–133.

Figure 16. Structures and cytotoxic effects of GA C-3 amino derivatives 129–133.

Figure 17. Structures and cytotoxic effects of miscellaneous compounds 134–155.

Figure 17. Structures and cytotoxic effects of miscellaneous compounds 134–155.

Figure 18. Structures and Pin1 inhibition of GA derivatives 156–164.

Figure 18. Structures and Pin1 inhibition of GA derivatives 156–164.