The potential of natural sources for pancreatic lipase inhibitors: a solution of the obesity crisis?

Figures & data

Figure 1. The chemical structures and IC₅₀ values of six known human pancreatic lipase (hPL) inhibitors.

Table 1. The inhibitory effects of orlistat and eight natural compounds against human pancreatic lipase (hPL) and porcine pancreatic lipase (pPL).

		IC50 (µM)
Compound	MW	hPL	pPL	IC50 ratio (hPL/pPL)
Orlistat	495.73	6.16 nM	0.75 nM	14.03
Sanggenon C	708.71	4.44 µM	3.00 µM	1.48
Hypericin	504.44	0.95 µM	0.97 µM	0.98
Ginkgetin	566.51	1.72 µM	2.03 µM	0.85
Isoginkgetin	566.51	2.25 µM	0.58 µM	3.88
Licochalcone A	338.4	18.03 µM	1.75 µM	10.30
Oleanonic acid	454.68	32.13 µM	0.49 µM	65.31
Epicatechin gallate	442.37	0.79 µM	>100 µM	<0.0079
Catechin gallate	442.37	0.041 µM	>100 µM	<0.004