Expert Opinion on Drug Discovery, Volume 17, Issue 12 (2022)

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Expert Opinion on Drug Discovery, Volume 17, Issue 12 (2022)

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Editorial

Editorial
The potential of natural sources for pancreatic lipase inhibitors: a solution of the obesity crisis?
Xu-Dong Hou, Xiao-Ya Qin, Jie Hou, Hui Tang & Guang-Bo Ge
Pages: 1295-1298
Published online: 12 Dec 2022
First Page PreviewforThe potential of natural sources for pancreatic lipase inhibitors: a solution of the obesity crisis? | Full Text | References | PDF (307.7 KB) | EPUB
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Drug Discovery Case History

Article
The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19)
Pasquale Pagliano, Carmine Sellitto, Tiziana Ascione, Giuliana Scarpati, Veronica Folliero, Ornella Piazza, Gianluigi Franci, Amelia Filippelli & Valeria Conti
Pages: 1299-1311
Published online: 12 Dec 2022
AbstractforThe preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19) | Full Text | References | PDF (2.5 MB) | EPUB
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Review

Review
Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy
Barbara Miziak & Stanisław J Czuczwar
Pages: 1313-1328
Published online: 24 Nov 2022
AbstractforApproaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy | Full Text | References | PDF (656.9 KB) | EPUB
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Review
The current progress in the use of boron as a platform for novel antiviral drug design
Shuo Wang, Yujie Ren, Zhao Wang, Xiangyi Jiang, Shujing Xu, Xujie Zhang, Shujie Zhao, Waleed A Zalloum, Xinyong Liu & Peng Zhan
Pages: 1329-1340
Published online: 05 Dec 2022
AbstractforThe current progress in the use of boron as a platform for novel antiviral drug design | Full Text | References | PDF (3.7 MB) | EPUB
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Review
Approaches for development of LAG-3 inhibitors and the promise they hold as anticancer agents
Martin Perez-Santos, Maricruz Anaya-Ruiz, Luis Villafaña-Diaz & Gabriela Sánchez Esgua
Pages: 1341-1355
Published online: 24 Nov 2022
AbstractforApproaches for development of LAG-3 inhibitors and the promise they hold as anticancer agents | Full Text | References | PDF (336.2 KB) | EPUB
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Review
Benzofuran as a promising scaffold for the synthesis of novel antimicrobial agents
Ashraf A. Abbas & Kamal M. Dawood
Pages: 1357-1376
Published online: 18 Dec 2022
AbstractforBenzofuran as a promising scaffold for the synthesis of novel antimicrobial agents | Full Text | References | PDF (2 MB) | EPUB
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Review
Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention
Israa A. Cheikh, Chirine El-Baba, Ali Youssef, Najat A. Saliba, Akram Ghantous & Nadine Darwiche
Pages: 1377-1405
Published online: 05 Dec 2022
AbstractforLessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Review
Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential
Shengxin Lu, Jiayi Lin, Jinmei Jin, Lijun Zhang, Yingyun Guan, Hongzhuan Chen, Ye Wu, Weidong Zhang & Xin Luan
Pages: 1407-1423
Published online: 27 Dec 2022
AbstractforTachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential | Full Text | References | PDF (4.7 MB) | EPUB
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Original Research

Article
Machine learning-based prediction of drug approvals using molecular, physicochemical, clinical trial, and patent-related features
Fulya Ciray & Tunca Doğan
Pages: 1425-1441
Published online: 13 Dec 2022
AbstractforMachine learning-based prediction of drug approvals using molecular, physicochemical, clinical trial, and patent-related features | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
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