Figures & data
Figure 1. Overview of simple genetic models (zebrafish, C. elegans and Drosophila) and rodent models that recapitulate ALS pathology. Abbreviations: LOF, loss of function; GOF, gain of function.
Figure 2. Translational value of ALS animal models for therapy. Summary of small compounds and other therapeutic strategies that have been identified in various animal models of ALS and are currently in clinical trials, with the corresponding phase of development.
Figure 3. Advantages and limitations of simple models (zebrafish, C. elegans and Drosophila) and rodent models for the translational research of new therapeutics for ALS.
