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Review

Graphene-based composites for biomedical applications

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , , , ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 724-748 | Received 13 Jul 2022, Accepted 21 Sep 2022, Published online: 07 Nov 2022

Figures & data

Figure 1. Typical graphene structure and their variants.

Figure 1. Typical graphene structure and their variants.

Figure 2. Hybrid graphene/Fe3O4 composites made by solvothermal reaction at 180°C. (A,B,C) TEM analysis of hybrid graphene/Fe3O4 composites made by solvothermal reaction at 4, 8, and 16 h, respectively; (D) HRTEM vision of boxed region of (C); (E, F) the subsequent SAED pattern and conventional EDS pattern of the hybrid composite graphene/Fe3O4. Reprinted from (Citation13) © 1999, the Royal Society of Chemistry.

Figure 2. Hybrid graphene/Fe3O4 composites made by solvothermal reaction at 180°C. (A,B,C) TEM analysis of hybrid graphene/Fe3O4 composites made by solvothermal reaction at 4, 8, and 16 h, respectively; (D) HRTEM vision of boxed region of (C); (E, F) the subsequent SAED pattern and conventional EDS pattern of the hybrid composite graphene/Fe3O4. Reprinted from (Citation13) © 1999, the Royal Society of Chemistry.

Figure 3. N-doped TiO2/graphene nano composite prepared at 180°C at varying reaction times of 7 h, 14 h, 21 h, respectively; (A, B, C), HRTEM micrograph (D), SAED pattern (E); and typical EDX pattern of N-doped TiO2 (F). Reprinted from (Citation15) © 1999, the Royal Society of Chemistry.

Figure 3. N-doped TiO2/graphene nano composite prepared at 180°C at varying reaction times of 7 h, 14 h, 21 h, respectively; (A, B, C), HRTEM micrograph (D), SAED pattern (E); and typical EDX pattern of N-doped TiO2 (F). Reprinted from (Citation15) © 1999, the Royal Society of Chemistry.

Figure 4. Different techniques of graphene producing. (a) Epitaxial growth; (b) chemical exfoliation; (c) chemical vapor deposition; (d) mechanical exfoliation; and (e) laser-assisted. Adapted from (Citation20) © 2012, Elsevier.

Figure 4. Different techniques of graphene producing. (a) Epitaxial growth; (b) chemical exfoliation; (c) chemical vapor deposition; (d) mechanical exfoliation; and (e) laser-assisted. Adapted from (Citation20) © 2012, Elsevier.

Figure 5. Schematic diagram showing expatial growth of graphene. Adapted from open access publication (Citation23) © 2018, MDPI.

Figure 5. Schematic diagram showing expatial growth of graphene. Adapted from open access publication (Citation23) © 2018, MDPI.

Figure 6. Schematic presentation of GBCs applications as biomaterials.

Figure 6. Schematic presentation of GBCs applications as biomaterials.

Figure 7. Schematic diagram showing graphene properties and its applications in biomedical. Adapted from open access publication (Citation16) © 2020, Taylor & Francis.

Figure 7. Schematic diagram showing graphene properties and its applications in biomedical. Adapted from open access publication (Citation16) © 2020, Taylor & Francis.

Figure 8. Potential application of GBCs as sensors for the medical field. (a) GB sensors for nervous system: schematic of graphene transistor (left) and their correspondent implant; (b) GB metabolic sensor; (c) GB bioelectrical electrode; (d) GB strain sensor; (e) GB sensor for nervous system: comparison between neural response to electrical stimulation with platinum and graphene electrode; (f) invasive sensor: The difference between tumor image captured with camera of the endoscope through metalelectronic devices (right) and transparent bioelectronic devices based on graphene (left). Adapted from open access publication (Citation111) © 2019, Frontiers.

Figure 8. Potential application of GBCs as sensors for the medical field. (a) GB sensors for nervous system: schematic of graphene transistor (left) and their correspondent implant; (b) GB metabolic sensor; (c) GB bioelectrical electrode; (d) GB strain sensor; (e) GB sensor for nervous system: comparison between neural response to electrical stimulation with platinum and graphene electrode; (f) invasive sensor: The difference between tumor image captured with camera of the endoscope through metalelectronic devices (right) and transparent bioelectronic devices based on graphene (left). Adapted from open access publication (Citation111) © 2019, Frontiers.

Figure 9. Graphene hybrid nanostructures for neuro-regenerative medicine. (a) Experimental substrates and (b) enhanced growth and alignment on GO-nanoparticle structure. Reprinted from (Citation121) © 2013, Wiley.

Figure 9. Graphene hybrid nanostructures for neuro-regenerative medicine. (a) Experimental substrates and (b) enhanced growth and alignment on GO-nanoparticle structure. Reprinted from (Citation121) © 2013, Wiley.

Figure 10. 3D graphene ink printed nerve conduits: (a) 3D graphene ink printed process; (b) SEM and optical (inset) images of graphene-PGA 3D printed; (c) uniaxial multichannel nerve guide of different size; and (d) nerve conduit of 3D graphene ink implanted in human cadaver. Reproduced with permission from (Citation129) © 2015, American Chemical Society.

Figure 10. 3D graphene ink printed nerve conduits: (a) 3D graphene ink printed process; (b) SEM and optical (inset) images of graphene-PGA 3D printed; (c) uniaxial multichannel nerve guide of different size; and (d) nerve conduit of 3D graphene ink implanted in human cadaver. Reproduced with permission from (Citation129) © 2015, American Chemical Society.