Figures & data
Figure 1. Degradation and secretion converge at the endolysosomal system. To ensure efficient function in the regulation of intracellular homeostasis, the endolysosomal system orchestrates endocytosis, MVB formation, exosome secretion, autophagy induction and lysosomal degradation, coordinating the balance between the degradation and secretion mechanisms. Clearance of damaged or toxic material, including proteins, lipids and nucleic acids through exosomes, secretory autophagy or secretory lysosomes might alleviate intracellular stress and contribute to the preservation of cellular homeostasis. ER: Endoplasmic reticulum, MVB: Multivesicular body; MTOC: Microtubule-organizing center.
