Pharmacological gating modulation of small- and intermediate-conductance Ca²⁺-activated K⁺ channels (K_Ca2.x and K_Ca3.1)

Figures & data

Figure 1. Membrane topology of a K_Ca2 channel and known sites of action of positive and negative gating modulators. Cam, calmodulin; CK2, casein kinase 2; PP2A, protein phosphatase 2A.

Figure 2. Top, chemical structures of positive and negative gating modulators. Bottom, schematic of effect of gating modulators on the channel Ca²⁺ concentration response curve.

Figure 3. Space-filled structure of NS309, calmodulin and K_Ca2.2 C-terminus complex. The K_Ca2.2 residues that become “ordered” following NS309 binding are shown in red.