Figures & data
Figure 1. Schematic representation of pH-sensing involved in ENT3 organelle transport. In lysosomes, residue Asp219 faces the acidic-pH, while the Glu447 is exposed to the cytosolic pH. However, in mitochondria, the Glu447 is exposed to the relatively acidic mitochondrial intermembrane space. It is hypothesized that the transport-permissible conformational changes occur in ENT3 when the amino acid lying in direct contact with the acidic-pH microenvironment gets protonated. Putative directionality for nucleoside transport indicated.
