http://orcid.org/0000-0001-5843-5961
Figures & data
Figure 1. The scheme of the unfolded protein response (UPR) signaling cascades and functions.
Figure 2. Tunicamycin-induced UPR activation alters the morphology of the action potential with prolonged action potential duration and decreased dV/dtmax of hiPSC-CMs, by decreasing all major cardiac ion channel currents.
Figure 3. A summarized scheme of the UPR regulation on human cardiac ion channels. Activated UPR downregulates selective ion channels, leads to prolonged APD and reduced dV/dtmax, which can contribute to electrical remodeling and arrhythmias. The PERK branch downregulates Nav1.5, Kv4.3, hERG, and KvLQT1, while the IRE1 branch downregulates Nav1.5, Cav1.2, hERG, and KvLQT1.
Figure 4. A summary of the UPR activation causing arrhythmias.
