The search for molecular mimicry in proteins carried by extracellular vesicles secreted by cells infected with Plasmodium falciparum

Figures & data

Figure 1. Venn diagram of Plasmodium falciparum 3D7 proteins reported in extracellular vesicles during parasite infection according to several authors

Table 1. Dali best results for P. falciparum molecular mimicry candidates vs human proteins

Predicted function	UniProt gene name P. falciparum	PDB ID P. falciparum	Best DALI result in humans	% of identity	RMSD
Glyceraldehyde-3-phosphate dehydrogenase	PF3D7_1462800	1YWG	6YND	64	0.8
Elongation factor 1-alpha	PF3D7_1357100	Predicted structure	3J5Y	37	5.5
Actin-1	PF3D7_1246200	6I4K	4FO0	22	2.0
Proteasome subunit alpha type	PF3D7_0727400	6MUW	6RGQ	46	1.5
Heat shock protein 90	PF3D7_0708400	3K60	6CEO	72	1.7
14-3-3 protein I	PF3D7_0818200	Predicted structure	3UBW	60	1.2
Fructose-bisphosphate aldolase	PF3D7_1444800	2PC4	1XFB	57	1.1
40S ribosomal protein S3	PF3D7_1465900	6OKK	5UBA	13	3.6

Figure 2. Superimposition of candidate proteins. (a) Heat shock protein 90, 6CEO (Homo sapiens) with 3K60 (P. falciparum). (b) Glyceraldehyde-3-phosphate dehydrogenase, 3GPD (Homo sapiens) with 1YWG (P. falciparum). (c) Elongation factor 1-alpha, 3C5J (Homo sapiens) with the homology predicted structure for (P. falciparum). (d) Fructose-aldose bisphosphate, 5LN3 (Homo sapiens) with 6MUX (P. falciparum). (e) Actin-1, 5 JLH (Homo sapiens) with 6I4K (P. falciparum). (f) Proteasome subunit alpha, 6REY (Homo sapiens) with 6MUW (P. falciparum). (g) 14-3-3 proteins, 3UVW (Homo sapiens) with the homology predicted structure for P. falciparum. (h) 40S ribosomal protein S3, 6YBS chain K (Homo sapiens) with 6OKK chain D (P. falciparum). The human proteins are represented in green and the P. falciparum proteins in light brown