Figures & data
Table 1. Demographics of HMS SIRS study populations.
Table 2. Comparison of plasma biomarkers and 28-day mortality.
Table 3. Multivariate analysis of plasma biomarkers association with clinical outcomes.
Table 4. Multivariate analysis of organism type association with clinical outcomes.
Figure 1. Scatter Plots of Circulating Plasma Biomarker Concentrations According to Bacterial Class IL-6, IL-8, sTNFR-1, granulocyte-colony stimulating factor, soluble FAS, soluble vascular cell adhesion molecule-1, and Ang2/Ang1 were measured in the plasma of 100 subjects meeting CDC criteria for bloodstream infection and sepsis within 24 of admission to the ICU. The graphs depict individual subjects (symbols) and a horizontal line representing the mean with vertical lines representing the standard error measures for each biomarker. Mann-Whitney U test was used to compare the medians of each biomarker. *:p < 0.05, ** p < 0.01.
Figure 2. sFAS Discriminates a Subset of Patients with Low APACHEIII who Subsequently Died of Sepsis.The measured values for soluble FAS and APACHEIII score were calculated for individual patients with sepsis from defined bloodstream infection. The values were plotted for each individual patient on an X and Y axis. The population was divided into four quadrants with the APACHEIII divided into populations above and below the clinically meaningful value of 50. Survivors are depicted with circles and nonsurvivors with triangles.
