Figure 1. Interaction of Saps with neutrophils and vaginal epithelium. Saps are capable of directly inducing neutrophil migration and are capable of inducing chemoattractive cytokines, macrophage inflammatory protein 2 (MIP-2) and interleukin 8 (IL-8) in vaginal epithelial cells to further enhance neutrophil recruitment. An unknown factor produced during experimental vaginal infection with C. albicans modulates the killing activity of neutrophils.
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