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Letter to the Editor

Persistent Zika virus infection in porcine conceptuses is associated with elevated in utero cortisol levels

ORCID Icon, , , , , & show all
Pages 1338-1343 | Received 04 Apr 2018, Accepted 23 Jul 2018, Published online: 26 Aug 2018

Figures & data

Table 1. Fetuses exposed to ZIKV/control media at 50 days of development and sampled at 110 days of development.

Figure 1. Cortisol levels in amniotic fluid of conceptuses. In accordance with physiological observations in humans [Citation31], AF cortisol levels increased from mid (78 gd) to later gestation (110 gd) in both control and ZIKV-affected litters. Numbers below X-axis represent average cortisol level in maternal plasma and the number of tested gilts (n). Fetal cortisol data from both control gilts on middle and right panels were combined because both gilts were sampled at 110 gd. Cortisol levels in fetuses were compared using two-sided Mann-Whitney U test (p-value). The line represents mean value. * – at 78 gd, maternal cortisol was measured only in one control gilt.

Figure 1. Cortisol levels in amniotic fluid of conceptuses. In accordance with physiological observations in humans [Citation31], AF cortisol levels increased from mid (78 gd) to later gestation (110 gd) in both control and ZIKV-affected litters. Numbers below X-axis represent average cortisol level in maternal plasma and the number of tested gilts (n). Fetal cortisol data from both control gilts on middle and right panels were combined because both gilts were sampled at 110 gd. Cortisol levels in fetuses were compared using two-sided Mann-Whitney U test (p-value). The line represents mean value. * – at 78 gd, maternal cortisol was measured only in one control gilt.

Table 2. Fetuses exposed to ZIKV/control media at 25 days of development and sampled at 110 days of development.

Table 3. Cortisol level in maternal blood plasma.

Supplemental material

Supplemental Material

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