https://orcid.org/0000-0002-7791-9782
Figures & data
Figure 1. InlA and InlB dependent breaching of the placental barrier by Listeria monocytogenes.
(a) The placental barrier between the maternal blood and the fetus lies in an epithelium, the syncytiotrophoblast, which results from the fusion of underlying cytotrophoblast cells. Syncytiotrophoblast expresses E-cadherin, which is accessible for bacteria in the maternal blood. (b) Listeria monocytogenes adheres to syncytiotrophoblast via InlA interaction with Ecad. InlB is required for L. monocytogenes entry by activating PI3-K via c-Met in the syncytiotrophoblast, leading to the actin cytoskeleton rearrangements needed for bacterial internalization.
