Figures & data
Figure 1. Cyclin dependent kinase 5 (CDK5) suppresses the production of IFN-β.
![Figure 1. Cyclin dependent kinase 5 (CDK5) suppresses the production of IFN-β.](/cms/asset/34a7b1f7-e950-43c7-b851-73ccbe6a9b0d/kvir_a_2223394_f0001_b.gif)
Figure 2. CDK5 deficiency promotes IFN-β production.
![Figure 2. CDK5 deficiency promotes IFN-β production.](/cms/asset/7caf24ce-ae54-43ef-812d-f3793cd08860/kvir_a_2223394_f0002_b.gif)
Figure 3. The regulation of CDK5 in IFN-β production is independent of its kinase activity.
![Figure 3. The regulation of CDK5 in IFN-β production is independent of its kinase activity.](/cms/asset/bd3a20d2-e323-4a00-aa5e-1ec1fc93be7b/kvir_a_2223394_f0003_b.gif)
Figure 4. CDK5 attenuates the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5).
![Figure 4. CDK5 attenuates the expression of retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5).](/cms/asset/0887cef6-60e5-47f2-8a0c-221e472f6152/kvir_a_2223394_f0004_b.gif)
Figure 5. CDK5 is associated with myeloid differentiation primary response gene 88 (MyD88) and suppresses TLR-MyD88-mediated signalling pathways.
![Figure 5. CDK5 is associated with myeloid differentiation primary response gene 88 (MyD88) and suppresses TLR-MyD88-mediated signalling pathways.](/cms/asset/e246814f-320d-43b5-84ac-4fd9404390c5/kvir_a_2223394_f0005_oc.jpg)
Figure 6. CDK5 negatively regulates the formation of MyD88 homodimers independent of its kinase activity.
![Figure 6. CDK5 negatively regulates the formation of MyD88 homodimers independent of its kinase activity.](/cms/asset/0fc591a9-b227-4a76-a531-4cfc2a73cb69/kvir_a_2223394_f0006_oc.jpg)
Supplemental Material
Download Zip (261 KB)Data availability statement
The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materialshttps://doi.org/10.6084/m9.figshare.23512494.