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Research Article

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans, reinforces the link between this fungal species and coeliac disease

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Article: 2334085 | Received 17 Oct 2023, Accepted 19 Mar 2024, Published online: 26 Mar 2024

Figures & data

Figure 1. Distribution of anti-Hwp1 antibodies (panel A) and ASCA (panel B) in sera from 78 patients with coeliac disease (CeD), 46 sera from 41 patients with C. albicans infection (IC) and 98 sera from healthy controls (HC). The significance of discrimination between the different groups is represented as the p value. A spearman correlation coefficient between ASCA titres and IgG anti-Hwp1 antibody titres (panel C) were calculated for raw data (black curve) and for data without outliers (red curve). Outliers points were automatically detected and eliminated by prism 10 software by applying a Q = 1%.

Figure 1. Distribution of anti-Hwp1 antibodies (panel A) and ASCA (panel B) in sera from 78 patients with coeliac disease (CeD), 46 sera from 41 patients with C. albicans infection (IC) and 98 sera from healthy controls (HC). The significance of discrimination between the different groups is represented as the p value. A spearman correlation coefficient between ASCA titres and IgG anti-Hwp1 antibody titres (panel C) were calculated for raw data (black curve) and for data without outliers (red curve). Outliers points were automatically detected and eliminated by prism 10 software by applying a Q = 1%.

Figure 2. Reactivity of sera from patients with coeliac disease (CeD) according to their adherence to a gluten-free diet (GFD) and sera from patients with C. albicans infection. 1= strict adherence to a GFD in the previous 2 months; 2 = no strict adherence to a GFD in the previous 2 months. IgA-tTG, IgAG-AG, anti-Hwp1 IgG, and ASCA results are expressed as optical density (450 nm), and all other results are expressed as AU.

Figure 2. Reactivity of sera from patients with coeliac disease (CeD) according to their adherence to a gluten-free diet (GFD) and sera from patients with C. albicans infection. 1= strict adherence to a GFD in the previous 2 months; 2 = no strict adherence to a GFD in the previous 2 months. IgA-tTG, IgAG-AG, anti-Hwp1 IgG, and ASCA results are expressed as optical density (450 nm), and all other results are expressed as AU.

Data Availability statement

The data that support the findings of this study are available on https://entrepot.recherche.data.gouv.fr/dataset.xhtml?persistentId=doi:10.57745/GUQ1QR