Maternal and neonatal outcomes and clinical laboratory testing of pregnant women with COVID-19 during the BA.5.2/BF.7 surge

Figures & data

Figure 1. Maternal and perinatal outcomes among pregnant women with and without SARS-CoV-2 infection.

Models adjusted for maternal age and high-risk pregnancy condition. Low Apgar refers to a newborn Apgar score of less than 7. HLOS, hospital length of stay. NICU, neonatal intensive care unit.

Figure 2. Comparison of blood routine test results upon admission for pregnant women, with or without SARS-CoV-2 infection, under different maternal and perinatal outcomes.

In the violin plot, the three dashed lines from top to bottom represent the upper, middle, and lower quartiles, respectively. The grey shaded area signifies the normal value range for this index in general adults. The numbers below the graph denote the median values. Mann-Whitney U test was used for statistical comparisons. Comparisons were also conducted between SARS-CoV-2 positive pregnant women with or without the results of NICU and HLOS ≥7 days, and only the significant p values were shown in the figures. ns, not significant. *, p < 0.05. **, p < 0.01. ***, p < 0.001. ****, p < 0.0001. HGB, haemoglobin. WBC, white blood cell. LY, lymphocyte. MO, macrophage. NE, neutrophil. PLT, platelet. HLOS, hospital length of stay. NICU, neonatal intensive care unit.

Figure 3. Comparison of coagulation test results upon admission for pregnant women, with or without SARS-CoV-2 infection, under different maternal and perinatal outcomes.

In the violin plot, the three dashed lines from top to bottom represent the upper, middle, and lower quartiles, respectively. The grey shaded area signifies the normal value range for this index in general adults. The numbers below the graph denote the median values. Mann-Whitney U test was used for statistical comparisons. Comparisons were also conducted between SARS-CoV-2 positive pregnant women with or without the results of NICU and HLOS ≥7 days, and only the significant p values were shown in the figures. ns, not significant. *, p < 0.05. **, p < 0.01. ****, p < 0.0001. APTT, activated partial thromboplastin time. INR, international normalized ratio. PT, prothrombin time. TT, thrombin time. FIB, fibrinogen. HLOS, hospital length of stay. NICU, neonatal intensive care unit.

Figure 4. Comparison of metabolic test results upon admission for pregnant women, with or without SARS-CoV-2 infection, under different maternal and perinatal outcomes.

In the violin plot, the three dashed lines from top to bottom represent the upper, middle, and lower quartiles, respectively. The grey shaded area signifies the normal value range for this index in general adults. The numbers below the graph denote the median values. Mann-Whitney U test was used for statistical comparisons. Comparisons were also conducted between SARS-CoV-2 positive pregnant women with or without the results of NICU and HLOS ≥7 days, and only the significant p values were shown in the figures. ns, not significant. *, p < 0.05. ALB, albumin. ALT, alanine aminotransferase. AST, aspartate aminotransferase. TBIL, total bilirubin. HLOS, hospital length of stay. NICU, neonatal intensive care unit.

Figure 5. In women with an HLOS of seven days or more, some laboratory test indices showed correlations with HLOS.

The symbol following the correlation coefficient represents the P-value, used to statistically test the significance of the correlation coefficient. P-values resulted from a two-tailed test for the Spearman rank correlation coefficient. FIB, fibrinogen. ALT, alanine aminotransferase. AST, aspartate aminotransferase. HLOS, hospital length of stay. ns, not significant. *, p < 0.05. ****, p < 0.0001.

Data availability statement

the Data generated during the study is available at repository “figshare” at https://figshare.com/articles/dataset/COVID-19_in_pregnant_women_original_data_csv/25764261 and lastly the reference number [10.6084/m9.figshare.25764261].