Figures & data
Figure 1. Trafficking and maturation of autophagic vesicles along microtubule networks. Molecular motors of the dynein and kinesin families promote retrograde and anterograde movement of autophagic vesicles, respectively. During their intracellular trafficking, autophagosomes fuse with lysosomes, leading to the formation of autolysosomes and subsequent degradation of autophagic cargo by lysosomal hydrolases. Association of Klp98A with lysosomes via Rab14 and with autophagosomes via Atg8 may provide a molecular bridge between these vesicles that physically supports the fusion event.
