Figures & data
Figure 1. Possible mechanisms by which Rab8 and Rab26 mediate the Golgi-to-cell surface transport of α2B-AR. A, Rab8 and Rab26 mediate 2 separate pathways that deliver the receptor to the cell surface. Rab8, in its inactive form presumably localized in the cytoplasm, interacts with the C-terminus of α2B-AR, whereas Rab26, in its active form tethered to the membrane, binds to the ICL3 of the receptor. B and C, Rab8 and Rab26 regulate α2B-AR transport at different steps in the same route. PM, plasma membrane.
