https://orcid.org/0000-0002-5661-4656
Figures & data
Figure 1. Quiescent endothelial cells rest on a laminin rich basement membrane matrix [Citation38] (blue). High RhoJ activity in these cells prevents fibronectin bundling and deposition as fibrils. RhoJ inhibits the uptake of ligand-bound α5β1 and diverts the receptors into a degradative fate. At the onset of angiogenic sprouting, a fibronectin rich provisional matrix is laid out (yellow). RhoJ inactivation by angiogenic growth factors promotes active α5β1 internalization and trafficking through the post-Golgi compartments to promote fibronectin fibrillogenesis
![Figure 1. Quiescent endothelial cells rest on a laminin rich basement membrane matrix [Citation38] (blue). High RhoJ activity in these cells prevents fibronectin bundling and deposition as fibrils. RhoJ inhibits the uptake of ligand-bound α5β1 and diverts the receptors into a degradative fate. At the onset of angiogenic sprouting, a fibronectin rich provisional matrix is laid out (yellow). RhoJ inactivation by angiogenic growth factors promotes active α5β1 internalization and trafficking through the post-Golgi compartments to promote fibronectin fibrillogenesis](/cms/asset/1d80774f-b26a-489f-aadc-ccdd1e561a05/ksgt_a_1809927_f0001_oc.jpg)