Figures & data
Figure 1. Maintenance of podocyte architecture by Rho GTPases.
The figure depicts the “slit-diaphragm constituted of cell-cell junctions at the baso-lateral membrane of podocytes, and the protein complexes driving the activation and control of RhoA, Cdc42 and Rac1 GTPases. Cdc42 controls polarization of podocytes through Par-6 complex while RhoA, activated by TRPC6, maintains cytoskeleton integrity, helped by Ubiquitin-ligase Smurf inhibition by Synaptopodin-long form (Syno-long). Synaptopodin also chelates IRSpI3 preventing it to interact with Wave 2 complex, and then inhibiting the Rac1 pathway. In the context of Rac1 activation, podocyte architecture is modified, and motility is activated.
