https://orcid.org/0000-0002-9708-2115
Figures & data
Figure 1. LARG and RhoA Downstream Effectors Mediating Cell Motility. ROCK, Rho-associated protein kinase, mDia, Diaphanous-related formin-1; LIMK, LIM kinases; MLC, Myosin Light Chain.
Figure 2. Domain structure of LARG and its regulation. Phosphorylation and sequences important for the regulation of LARG activation and localization are indicated. NLS, nuclear localization signal; PDZ, post-synaptic density 95; disk large, zona occludens-1; RH, RGS homology; DH, Dbl homology; PH, Pleckstrin homology; CC, coiled-coil domain.
Figure 3. LARG activation and regulation. primary pathways of LARG activation in cell migration and invasion are depicted. Upon GPCR, EGFR/integrin binding to cognate ligands LARG can be activated by either Gα proteins or ERK/RSK respectively. Not shown are undefined tyrosine phosphorylations in the c-terminus that can also mediate activation via FAK or Fyn kinases. Dia1 can alternatively activate LARG GEF activity by binding to the coiled-coil region.
Figure 4. LARG Physiological Function. Depicted are known physiological functions of LARG/ARHGEF12 and potential therapeutic value of targeting LARG in each.
