Figures & data
Figure 1. Differential regulation of human dendritic cells by B cells dependent on activation stimuli. B cells activated by B-cell receptor (BCR)-signaling induce maturation of dendritic cells (DCs) through contact-dependent mechanisms. B–cell-matured DCs are capable of polarizing the naïve CD4+ Th cells to Th2 cells through OX-40 ligand (OX-40L)-signaling. Th2 cells secrete cytokines such as interleukin (IL)-4, IL-5, and IL-13, which could promote development of B cells into antibody-producing plasma cells. Conversely, B cells activated by CpG (Toll-like receptor (TLR) 9 ligand) interfere with the differentiation of monocytes into DCs and inhibit the TLR (lipopolysaccharide [LPS], a TLR4 ligand)-mediated maturation of DCs.
![Figure 1. Differential regulation of human dendritic cells by B cells dependent on activation stimuli. B cells activated by B-cell receptor (BCR)-signaling induce maturation of dendritic cells (DCs) through contact-dependent mechanisms. B–cell-matured DCs are capable of polarizing the naïve CD4+ Th cells to Th2 cells through OX-40 ligand (OX-40L)-signaling. Th2 cells secrete cytokines such as interleukin (IL)-4, IL-5, and IL-13, which could promote development of B cells into antibody-producing plasma cells. Conversely, B cells activated by CpG (Toll-like receptor (TLR) 9 ligand) interfere with the differentiation of monocytes into DCs and inhibit the TLR (lipopolysaccharide [LPS], a TLR4 ligand)-mediated maturation of DCs.](/cms/asset/525c7ab6-31b0-4f40-9e7c-c1a440854eab/koni_a_1005508_f0001_oc.jpg)