Figure 1. Genetic evolution of T-cell resistance in melanoma in the course of disease progression. The HLA class I-negative phenotype of T–cell-resistant melanoma cells is caused by the lack of B2M expression that, in turn, originates from an early-acquired deletion on chromosome 15q, including 1 B2M allele, followed by mutational inactivation of the remaining B2M gene. wt, wild type.
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