Figures & data
Figure 1. Schematic representation of bidirectional signal transduction for the CD137 receptor/ligand system and its effects on antigen presenting cells (APC), T cells and natural killer (NK) cells.
Figure 2. The effects of agonistic anti-CD137 antibodies on type 1 polarization which promotes (green arrows) anticancer immune responses and inhibits (red lines) type 2-mediated autoimmune reactions.
Figure 3. The effects of inhibition of CD137–CD137L interaction by antagonistic anti-CD137 or anti-CD137L antibodies on the bidirectional signal transduction for the CD137 receptor/ligand system is depicted exemplary for the case of an APC–T cell interaction.
