Figures & data
Figure 1. Negative impact of apoptotic caspases on the immunogenicity of radiation therapy.
The immunogenicity of cancer cells succumbing to irradiation is largely dependent on type I IFN secretion (IFN). In this context, apoptotic caspases like caspase 3 (CASP3) mediate a detrimental effect as they drive the terminal inactivation and structural breakdown of dying cells. Thus, caspase inhibition with emricasan stands out as a promising approach to boost the efficacy of radiation therapy in the clinic.
