Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapy

Figures & data

Figure 1. As a function of time, X axis, neutrophil blood cell (blue), lymphocyte (orange) counts of the patient are depicted on the left Y axis. As a function of time (X axis) neutralizing antibody levels of the patient (values at black dots, anti-RBD IgG, right Y axis) are shown during and after Vepesid cytostatic treatment. Anti-COVID vaccinations with Pfizer-BioNTech (on days 125, 146, 224) and Sinopharm (on day 370) are shown on the top with green and red arrows, respectively. Green line connects IgG levels in response to Pfizer’s-, red line for Sinopharm vaccinations, whereas blue line after silent Covid-19 infection. Also, the times of negative PCR tests are shown (black arrows). The figure clearly indicates that the first two Pfizer vaccinations did not elicit increase in IgG, whereas the 3^rd Pfizer vaccination resulted in very high level of IgG response despite of low level of neutrophil and lymphocytes. Sinopharm elicited only modest increase (despite the normal levels of neutrophils and lymphocytes, in contrast a silent Covid-19 infection again elicited a great increase in IgG level, indicating proper activation of the immune system.

Table 1. Complement proteins 1 month after the first vaccination with Comirnaty.

Analyte	Values	Reference range
Classic total complement (CH50/mL)	94	48–103
C1q (mg/mL)	114	60–180
C3 (g/L)	1.18	0.90–1.80
C4 (g/L)	0.54	0.15–0.55
Alternative total complement	100.00	70.00–125.00
B Factor (mq/L)	129%	70–130
I Factor (mq/L)	85%	70–130
H Factor (mq/L)*	962.00	250.00–880

Table 2. Anti-PEG IgM levels after three vaccinations with Comirnaty.

Date of vaccination	Date of measurement	Days after preceding vaccination	Anti-PEG IgM concentration [ngeq/ml]	Normal range
2021/1/10	2021.01.12.	2	5	<250
2021/1/31	2021.02.10.	10	65
2021/4/19	2021.05.04.	15	37
	2021.05.25.	26	8

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.