Clinical significance of the serum miR-455-5p expression in patients with neonatal sepsis

Figures & data

Table 1. Clinical data of the study population

Parameters	Subjects (N = 178)		P
	Healthy individuals (n = 88)	Neonatal sepsis (n = 90)
Age (days)	11.41 ± 5.10	10.21 ± 4.04	0.084
Body weight (kg)	3.39 ± 0.53	3.40 ± 0.46	0.976
Gender (male/female)	37/51	43/47	0.442
WBC (×10^9/L)	8.02 ± 3.10	17.51 ± 6.04	<0.001
CRP (mg/L)	4.87 ± 3.27	15.20 ± 4.30	<0.001
PCT (ng/mL)	0.17 ± 0.05	10.69 ± 5.11	<0.001
NLR	1.22 ± 0.3	5.38 ± 2.21	<0.001

WBC, white blood cell; CRP, C-reactive protein; PCT, procalcitonin; NLR, neutrophil–lymphocyte ratio. Data are expression mean ± standard deviation.

Figure 1. The relative expression of miR-455-5p in NS patients. *** P < 0.001

Table 2. Correlation between miR-455-5p and clinical characteristics

Characteristics	N	Correlation with miR-455-5p (r)	P-value
WBC (×10^9/L)	90	0.382	0.001
CRP (mg/L)	90	0.392	<0.001
PCT (ng/mL)	90	0.308	0.003
NLR	90	0.346	0.001
IL-6 (pg/mL)	90	0.360	<0.001
IL-8 (pg/mL)	90	0.308	0.003
TNF-α (pg/mL)	90	0.486	<0.001

WBC, white blood cell; CRP, C-reactive protein; PCT, procalcitonin; IL-6, interleukin-6; IL-8, interleukin – 8; TNF-α, tumor necrosis factor -alpha; NLR, neutrophil – lymphocyte ratio.

Figure 2. The diagnostic value of miR-455-5p was assessed by the ROC curve analysis. the AUC was 0.895, with the sensitivity of 80.2% and the specificity of 85.2%

Table 3. Multivariate Cox analysis of clinical characteristics in relation to overall survival

Characteristics	Multivariate analysis
	HR	95% CI	P
MiR-455-5p	3.454	1.165–10.234	0.025
Age (days)	1.430	0.601–3.405	0.419
Body weight (kg)	1.252	0.547–2.867	0.595
Gender (male/female)	1.399	0.596–3.283	0.441
WBC (×10^9/L)	2.021	0.850–4.806	0.112
CRP (mg/L)	1.411	0.620–3.212	0.411
PCT (ng/mL)	2.432	1.000–5.914	0.050
NLR	1.464	0.642–3.336	0.365

Abbreviations: WBC, white blood cell; CRP, C-reactive protein; PCT, procalcitonin; NLR, neutrophil–lymphocyte ratio.

Figure 3. Kaplan-Meier survival curves of NS patients with different miR-455-5p expression levels

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.