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Bioengineered Volume 12, 2021 - Issue 1
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Research Paper

MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8

Yingying Yua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Guojing Lia Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Xiaoying Hea Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Yu Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Zheng Chena Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
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Xianhua Lina Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaView further author information
&
Hong Xua Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China;b Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China;c Shanghai Municipal Key Clinical Specialty, Shanghai, ChinaCorrespondence[email protected]
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Pages 5789-5796 | Received 13 Jun 2021, Accepted 12 Aug 2021, Published online: 13 Sep 2021

Figures & data

Figure 1. High expression of TLR8 and miR-21 in PCOS ovarian granulosa cells

(a) Relative mRNA expression of TLR8 and miR-21 in PCOS ovarian granulosa cells, (b) Relative protein expression of TLR8 in PCOS ovarian granulosa cells.
Figure 1. High expression of TLR8 and miR-21 in PCOS ovarian granulosa cells

Figure 2. Binding verification of miR-21 and TLR8 by double luciferase reporter gene

Figure 2. Binding verification of miR-21 and TLR8 by double luciferase reporter gene

Figure 3. miR-21 regulate the expression of TLR8, IFN-γ,TNF-α, and IL-12

(a) Relative mRNA expression of TLR8, IFN-γ, TNF-α, and IL-12, (b) Protein expression of TLR8, IFN-γ, TNF-α, and IL-12.
Figure 3. miR-21 regulate the expression of TLR8, IFN-γ,TNF-α, and IL-12

Figure 4. The effect of miR-21 on the cell apoptosis and cell proliferation of PCOS granulosa cells

(a) the cell apoptosis of PCOS granulosa cells, (b) HE staining images of PCOS granulosa cells, (c) The cell proliferation of PCOS granulosa cells.
Figure 4. The effect of miR-21 on the cell apoptosis and cell proliferation of PCOS granulosa cells

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