Figures & data
Figure 1. The effect of carvedilol on cell viability of LPS-induced BEAS2B cells. (a) The cell viability of BEAS2B cells treated with carvedilol. (b) The cell viability of LPS-induced BEAS2B cells treated with carvedilol. ***P < 0.001 Versus Control, ###P < 0.001 Versus LPS.
![Figure 1. The effect of carvedilol on cell viability of LPS-induced BEAS2B cells. (a) The cell viability of BEAS2B cells treated with carvedilol. (b) The cell viability of LPS-induced BEAS2B cells treated with carvedilol. ***P < 0.001 Versus Control, ###P < 0.001 Versus LPS.](/cms/asset/c7bda6c2-28a8-4727-894b-4558959a5853/kbie_a_2011013_f0001_b.gif)
Figure 2. Carvedilol reduces the expression of RhoA and ROCK in LPS-induced BEAS2B cells. (a-b) The expression of RhoA in LPS-induced BEAS2B cells. (c) The expression of MYPT1 in LPS-induced BEAS2B cells. ***P < 0.001 Versus Control, ###P < 0.001 Versus LPS.
![Figure 2. Carvedilol reduces the expression of RhoA and ROCK in LPS-induced BEAS2B cells. (a-b) The expression of RhoA in LPS-induced BEAS2B cells. (c) The expression of MYPT1 in LPS-induced BEAS2B cells. ***P < 0.001 Versus Control, ###P < 0.001 Versus LPS.](/cms/asset/6415093d-ebe4-4c34-ab52-e751a85b98d7/kbie_a_2011013_f0002_b.gif)
Figure 3. Carvedilol reduces the cell viability, inflammation and oxidative stress of LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. (a-b) The expression of RhoA after the plasmid overexpressing RhoA was constructed. ***P < 0.001 Versus Ov-NC. (c) The cell viability of LPS-induced BEAS2B cells transfected with Ov-RhoA. (d) The expression of inflammatory cytokines in LPS-induced BEAS2B cells transfected with Ov-RhoA, detected by ELISA. (e) The expression of inflammation-related markers in LPS-induced BEAS2B cells transfected with Ov-RhoA, detected by Western blot. (f) The levels of ROS, MDA, and SOD in LPS-induced BEAS2B cells transfected with Ov-RhoA *P < 0.05, ***P < 0.001 Versus LPS. ###P < 0.001 Versus LPS+5 µM+Ov-NC.
![Figure 3. Carvedilol reduces the cell viability, inflammation and oxidative stress of LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. (a-b) The expression of RhoA after the plasmid overexpressing RhoA was constructed. ***P < 0.001 Versus Ov-NC. (c) The cell viability of LPS-induced BEAS2B cells transfected with Ov-RhoA. (d) The expression of inflammatory cytokines in LPS-induced BEAS2B cells transfected with Ov-RhoA, detected by ELISA. (e) The expression of inflammation-related markers in LPS-induced BEAS2B cells transfected with Ov-RhoA, detected by Western blot. (f) The levels of ROS, MDA, and SOD in LPS-induced BEAS2B cells transfected with Ov-RhoA *P < 0.05, ***P < 0.001 Versus LPS. ###P < 0.001 Versus LPS+5 µM+Ov-NC.](/cms/asset/6f81c846-d489-46d9-a437-e236682d6e5e/kbie_a_2011013_f0003_b.gif)
Figure 4. Carvedilol reduces apoptosis of LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. (a-b) The apoptosis of LPS-induced BEAS2B cells transfected with Ov-RhoA. ***P < 0.001 Versus LPS. ###P < 0.001 Versus LPS+5 µM+Ov-NC.
![Figure 4. Carvedilol reduces apoptosis of LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. (a-b) The apoptosis of LPS-induced BEAS2B cells transfected with Ov-RhoA. ***P < 0.001 Versus LPS. ###P < 0.001 Versus LPS+5 µM+Ov-NC.](/cms/asset/f67f6a68-3d99-4f7b-9b19-fee9e7ad4416/kbie_a_2011013_f0004_oc.jpg)
Figure5. Carvedilol affects the expression levels of apoptosis-related proteins in LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. The expression of apoptosis-related proteins, including Bax, Bad, cleaved caspase3 and Bcl-2 in LPS-induced BEAS2B cells transfected with Ov-RhoA. ***P < 0.001 Versus LPS. ##P < 0.01, ###P < 0.001 Versus LPS+5 µM+Ov-NC.
![Figure5. Carvedilol affects the expression levels of apoptosis-related proteins in LPS-induced BEAS2B cells by inhibiting RhoA/ROCK activities. The expression of apoptosis-related proteins, including Bax, Bad, cleaved caspase3 and Bcl-2 in LPS-induced BEAS2B cells transfected with Ov-RhoA. ***P < 0.001 Versus LPS. ##P < 0.01, ###P < 0.001 Versus LPS+5 µM+Ov-NC.](/cms/asset/7446db00-252b-4deb-9df8-5571ef1f29f7/kbie_a_2011013_f0005_b.gif)