Carvedilol alleviates lipopolysaccharide (LPS)-induced acute lung injury by inhibiting Ras homolog family member A (RhoA)/ROCK activities

References

• Li Y, Huang J, Foley NM, et al. B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration. Sci Rep. 2016;6(1):31284.
   PubMedGoogle Scholar
• Lederer PA, Zhou T, Chen W, et al. Mathew B and Jacobson JR. Attenuation of murine acute lung injury by PF-573,228, an inhibitor of focal adhesion kinase. Vascul Pharmacol. 2018;110:16–23.
   PubMed Web of Science ®Google Scholar
• Kallet RH, Lipnick MS, Pirracchio R. Acute Respiratory Distress Syndrome Outcomes in Non-Research Subjects Assessed by Generalized Prospective Trial Eligibility Criteria and Adherance to Lung-Protective Ventilation. Respir Care. 2021;66(9):1380–1388.
   PubMed Web of Science ®Google Scholar
• Krupa A, Fol M, Rahman M, et al. Rosenfield GR and Kurdowska AK. Silencing Bruton’s tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014;307(6):L435–448.
   PubMed Web of Science ®Google Scholar
• Zhang QL, Yang JJ, Zhang HS. Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy. Biomed Pharmacother. 2019;109:71–83.
   PubMed Web of Science ®Google Scholar
• Bhardwaj A, Kedarisetty CK, Vashishtha C, et al. Bhatia V and Sarin SK. Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial. Gut. 2017;66(10):1838–1843.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang M. Carvedilol protection against endogenous Abeta-induced neurotoxicity in N2a cells. Cell Stress Chaperones. 2018;23(4):695–702.
   PubMed Web of Science ®Google Scholar
• Helal MG, Said E. Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFbeta1 signaling. Int Immunopharmacol. 2019;70:47–55.
   PubMed Web of Science ®Google Scholar
• Byrne KM, Monsefi N, Dawson JC, et al. von Kriegsheim A and Kholodenko BN. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. Cell Syst. 2016;2(1):38–48.
   PubMed Web of Science ®Google Scholar
• Wu X, Liu J, Zhang J, et al. Sun B and Zhou H. Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy. Mol Med Rep. 2016;13(3):2385–2392.
   PubMed Web of Science ®Google Scholar
• Horii Y, Uchiyama K, Toyokawa Y, et al. Naito Y and Itoh Y. Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2. Food Funct. 2016;7(7):3176–3183.
   PubMed Web of Science ®Google Scholar
• Wu Y, Li Z, Wang S. Xiu A and Zhang C. Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway. Biomed Res Int. 2019;2019:7932046.
   PubMed Web of Science ®Google Scholar
• Feng G, Sun B, Liu HX, et al. Zhao L and Wang TL. EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways. Int Immunopharmacol. 2019;72:176–185.
   PubMed Web of Science ®Google Scholar
• Niu X, Zang L, Li W, et al. Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway. Int Immunopharmacol. 2020;81:106024.
   PubMed Web of Science ®Google Scholar
• Ju M, Liu B, He H, et al. MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway. Cell Cycle. 2018;17(16):2001–2018.
   PubMed Web of Science ®Google Scholar
• Wang YM, Ji R, Chen WW, et al. Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway. Drug Des Devel Ther. 2019;13:3391–3404.
   PubMed Web of Science ®Google Scholar
• Mazzei M, Vascellari M, Zanardello C, et al. Quantitative real time polymerase chain reaction (qRT-PCR) and RNA scope in situ hybridization (RNA-ISH) as effective tools to diagnose feline herpesvirus-1-associated dermatitis. Vet Dermatol. 2019;30(6):491–e147.
   PubMed Web of Science ®Google Scholar
• Liu B, Lee YC, Alwaal A, et al. Carbachol-induced signaling through Thr696-phosphorylation of myosin phosphatase-targeting subunit 1 (MYPT1) in rat bladder smooth muscle cells. Int Urol Nephrol. 2016;48(8):1237–1242.
   PubMed Web of Science ®Google Scholar
• Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010;23(4):243–252.
   PubMed Web of Science ®Google Scholar
• McDowell HR, Chuah CS, Tripathi D, et al. Forrest EH and Hayes PC. Carvedilol is associated with improved survival in patients with cirrhosis: a long-term follow-up study. Aliment Pharmacol Ther. 2021;53(4):531–539.
   PubMed Web of Science ®Google Scholar
• Kumar M, Kainth S, Choudhury A, et al. Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial. Hepatol Int. 2019;13(6):800–813.
   PubMed Web of Science ®Google Scholar
• Fujita Y, Yamashita T. Axon growth inhibition by RhoA/ROCK in the central nervous system. Front Neurosci. 2014;8:338.
   PubMed Web of Science ®Google Scholar
• Loirand G. Rho Kinases in Health and Disease: from Basic Science to Translational Research. Pharmacol Rev. 2015;67(4):1074–1095.
   PubMed Web of Science ®Google Scholar
• Yan Q, Wang X, Zha M, et al. The RhoA/ROCK signaling pathway affects the development of diabetic nephropathy resulting from the epithelial to mesenchymal transition. Int J Clin Exp Pathol. 2018;11(9):4296–4304.
   PubMed Web of Science ®Google Scholar
• Abedi F, Hayes AW, Reiter R. Reiter R and Karimi G. Acute lung injury: the therapeutic role of Rho kinase inhibitors. Pharmacol Res. 2020;155:104736.
   PubMed Web of Science ®Google Scholar
• Wang Y, Shou Z, and Fan H, et al. Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway. Biosci Rep. 2019;39(7):BSR20182297.
   Web of Science ®Google Scholar
• Qian X, Zhu M, Qian W, et al. Vitamin D attenuates myocardial ischemia-reperfusion injury by inhibiting inflammation via suppressing the RhoA/ROCK/NF-kB pathway. Biotechnol Appl Biochem. 2019;66(5):850–857.
   PubMed Web of Science ®Google Scholar