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Bioengineered Volume 13, 2022 - Issue 2
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Research Paper

Fumitremorgin C alleviates advanced glycation end products (AGE)-induced chondrocyte inflammation and collagen II and aggrecan degradation through sirtuin-1 (SIRT1)/nuclear factor (NF)-κB/ mitogen-activated protein kinase (MAPK)

Yeli ZhouDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
,
Jing LiDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
,
Chenglong WangDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
&
Zheer PanDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaCorrespondence[email protected]
View further author information
Pages 3867-3876 | Received 02 Sep 2021, Accepted 25 Dec 2021, Published online: 02 Feb 2022

Figures & data

Figure 1. Fumitremorgin C elevates the cell viability of AGE-induced SW1353 cells. (a) The cell viability of SW1353 cells exposed to fumitremorgin C. (b) The cell viability of AGE-induced SW1353 cells exposed to fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ##P < 0.01 Versus AGE. Fu C: Fumitremorgin C.

Figure 1. Fumitremorgin C elevates the cell viability of AGE-induced SW1353 cells. (a) The cell viability of SW1353 cells exposed to fumitremorgin C. (b) The cell viability of AGE-induced SW1353 cells exposed to fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ##P < 0.01 Versus AGE. Fu C: Fumitremorgin C.

Figure 2. Fumitremorgin C alleviates AGE-induced SW1353 cell inflammation. The expression of TNF-α, IL-1β, and IL-6 in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. ##P < 0.01, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 2. Fumitremorgin C alleviates AGE-induced SW1353 cell inflammation. The expression of TNF-α, IL-1β, and IL-6 in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. ##P < 0.01, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 3. Fumitremorgin C alleviates ECM degradation in AGE-induced SW1353 cells. (a) The expression of collagen II and (b) ECM-related proteins in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 3. Fumitremorgin C alleviates ECM degradation in AGE-induced SW1353 cells. (a) The expression of collagen II and (b) ECM-related proteins in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 4. Fumitremorgin C alleviates ECM degradation in AGE-induced SW1353 cells. (a) The expression of Aggrecan and (b, c) ECM-related proteins in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 4. Fumitremorgin C alleviates ECM degradation in AGE-induced SW1353 cells. (a) The expression of Aggrecan and (b, c) ECM-related proteins in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 5. Fumitremorgin C inhibits the expression of NF-KB/MAPK signal by activating SIRT1. The proteins in NF-KB/MAPK signal were measured in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ##P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 5. Fumitremorgin C inhibits the expression of NF-KB/MAPK signal by activating SIRT1. The proteins in NF-KB/MAPK signal were measured in AGE-induced SW1353 cells pretreated with fumitremorgin C. ***P < 0.001 Versus Control. #P < 0.05, ##P < 0.05, ###P < 0.001 Versus AGE. Fu C: Fumitremorgin C.

Figure 6. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on AGE-induced SW1353 cell inflammation. The expression of TNF-α, IL-1β, and IL-6 in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@P < 0.01, @@@P < 0.001 Versus + AGE+Fu C. Fu C: Fumitremorgin C.

Figure 6. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on AGE-induced SW1353 cell inflammation. The expression of TNF-α, IL-1β, and IL-6 in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@P < 0.01, @@@P < 0.001 Versus + AGE+Fu C. Fu C: Fumitremorgin C.

Figure 7. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on ECM degradation in AGE-induced SW1353 cells. (a) The expression of collagen II and (b, c) ECM-related proteins in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@P < 0.01, @@@P < 0.001 Versus + AGE +Fu C. Fu C: Fumitremorgin C.

Figure 7. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on ECM degradation in AGE-induced SW1353 cells. (a) The expression of collagen II and (b, c) ECM-related proteins in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@P < 0.01, @@@P < 0.001 Versus + AGE +Fu C. Fu C: Fumitremorgin C.

Figure 8. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on ECM degradation in AGE-induced SW1353 cells. (a) The expression of Aggrecan and (b, c) ECM-related proteins in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@@P < 0.001 Versus + AGE+Fu C. Fu C: Fumitremorgin C.

Figure 8. SIRT1 inhibitor EX527 reverts the repressive effects of fumitremorgin C on ECM degradation in AGE-induced SW1353 cells. (a) The expression of Aggrecan and (b, c) ECM-related proteins in AGE-induced SW1353 cells treated with fumitremorgin C and EX527. ***P < 0.001 Versus Control. ###P < 0.001 Versus AGE. @@@P < 0.001 Versus + AGE+Fu C. Fu C: Fumitremorgin C.

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