Incidence of amyotrophic lateral sclerosis in the United States, 2014–2016

Figures & data

Table 1 Age-adjusted incidence rates, United States, 2014–2016.

Year	2014		2015		2016
Characteristic	No. (%) cases	Age-adjusted standardized incidence rate, (95% CI)^a	No. (%) cases	Age-adjusted standardized incidence rate, (95% CI)^a	No. (%) cases	Age-adjusted standardized incidence rate, (95% CI)^a
Total	5,695	1.75 (1.70, 1.86)	6,045	1.57 (1.53, 1.62)	4,861	1.56 (1.51, 1.61)
Gender
Male	3,088 (54.2)	2.19 (2.11, 2.28)	3,174 (52.5)	2.66 (2.55, 2.77)	3,118 (64.1)	2.61 (2.51, 2.71)
Female	2,178 (38.2)	1.24 (1.19, 1.30)	2,708 (44.8)	1.89 (1.81, 1.97)	1,740 (35.8)	1.01 (0.96, 1.06)
Unknown	429 (7.5)		163 (2.7)		2 (0)
Race
White	4,727 (83.0)	1.80 (1.75, 1.86)	4,962 (82.1)	1.62 (1.57, 1.67)	3,733 (76.8)	1.56 (1.51, 1.61)
Black	333 (5.8)	1.05 (0.93, 1.17)	365 (6.0)	1.02 (0.90, 1.13)	335 (6.9)	1.07 (0.95, 1.18)
Other	254 (4.5)	1.15 (1.00, 1.31)	325 (5.4)	1.48 (1.31, 1.66)	224 (4.6)	1.15 (1.00, 1.31)
Unknown	381 (6.7)		393 (6.5)		569 (11.7)

^aIncidence rate: per 100,000 population.

Table 2 Age-adjusted incidence rates by age group, 2014–2016.

Age Groups (yrs)	2014^a	2015^a	2016^a
18−39	0.1	0.1	0.1
40−49	0.9	0.5	0.6
50−59	2.0	1.4	1.6
60−69	4.4	4.3	4.2
70−79	7.0	7.9	7.1
≥80	5.7	4.0	3.9

^aIncidence rate: per 100,000 population.

Table 3 Age-adjusted incidence rates by Census regions, United States, 2014–2016.

Year/Region+	No. cases (%)	Age-adjusted standardized incidence rate, (95% CI)^a
2014
Region 1 - NE	1,060 (18.6)	1.91 (1.79, 2.03)
Region 2 - MW	1,984 (34.8)	2.85 (2.72, 2.99)
Region 3 - South	1,305 (22.9)	1.00 (0.94, 1.06)
Region 4 - West	1,112 (19.5)	1.59 (1.49, 1.69)
Unknown	234 (4.1)
2015
Region 1 - NE	960 (15.9)	1.52 (1.41, 1.63)
Region 2 - MW	1,925 (31.8)	2.63 (2.50, 2.76)
Region 3 - South	1,297 (21.5)	0.99 (0.93, 1.05)
Region 4 - West	1,202 (19.9)	1.56 (1.46, 1.66)
Unknown	661 (10.9)
2016
Region 1 - NE	891 (18.3)	1.70 (1.59, 1.82)
Region 2 - MW	1,536 (31.6)	2.50 (2.37, 2.62)
Region 3 - South	1,009 (20.8)	0.90 (0.85, 0.96)
Region 4 - West	899 (18.5)	1.39 (1.30, 1.48)
Unknown	526 (10.8)

^aIncidence rate: per 100,000 population.

+ Region: Northeast: Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont; South: Alabama, Arkansas, Delaware, District of Columbia, Florida, Georgia, Kentucky, Louisiana, Maryland, Mississippi, North Carolina, Oklahoma, South Carolina, Tennessee, Texas, Virginia, West Virginia; Midwest: Iowa, Illinois, Indiana, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, Wisconsin; West: Alaska, Arizona, California, Colorado, Hawaii, Idaho, Montana, Nevada, New Mexico, Oregon, Utah, Washington, Wyoming.