Augmentation of therapeutic potential of curcumin using nanotechnology: current perspectives

Figures & data

Figure 1. Pleotrophic therapeutic effects of curcumin.

Table 1. Different formulations of curcumin.

S. No.	Formulation	Curcumin combination	Advantage	References
1	Solid dispersions	Curcumin-polyvinylpyrrolidone K-30 ratioof 1:6	Increased solubility and dispersion	[20]
		Curcumin-D-α-tocopheryl polyethyleneglycol 1000 succinate (TPGS) and mannitol	Increased solubility, dissolution rate and cell permeability	[35]
		Curcumin-PVP	Improved dissolution and bioavailability	[36]
2	Microemulsion	Curcumin in O/W emulsion of Triacylglycerol and Tween 20	Enhanced anti-inflammatory activity	[37]
		Curcumin in capryol oil, cremophor RH 40 and transcutol P	Improved oral bioavailability	[38]
		Curcumin in soybean oil/lecithin	Improved cytotoxic effect	[39]
3	Excipient emulsions	Curcumin in excipient emulsion of corn oil in water	Enhanced bioaccessibility	[40]
4	Encapsulation	Curcumin encapsulated in hydrophobically modified starch	Increased solubility and enhancedanti-cancer activity	[22]
		Curcumin encapsulated into silane-hydrogel nanoparticle	Improved antimicrobial and woundhealing property	[41]
		Curcumin encapsulated in nanogels	Effective anticancer activity	[42]
5	Complex formation	Curcumin with cyclodextrin	Improvement in water solubility, hydrolytic and photochemical stability	[23]
		Curcumin with γ-cyclodextrin	Improvement in the absorption ofcurcuminoids in healthy humans.	[43]
6	Liposomes (nanodelivery vehicles)	Curcumin-loaded liposomes	Enhanced anticancer activity	[44–46]
7	Nanoparticulate formulation	Curcumin-loaded PLGA nanoparticles (poly(D,L-lactide-co-glycolide)	Enhanced cellular uptake and increased bioactivity in inducing apoptosis and suppressing proliferation of tumour cells	[47]
8	Conjugation with magnetic nanoparticles	Fe3O4-curcumin conjugate	Improved cellular uptake and waterdispersibility. Potent anticancer activity. Also used an imaging probe.	[48–50]
9	Micelles	Curcumin encapsulation in copolymer poly(L-lactic acid) based poly(anhydride-ester)-b-poly(ethylene glycol) (PAE-b-PEG) micelle	Improved anti-cancer activity	[51]
		Curcumin encapsulated in cationic micelles composed of surfactants cetyl trimethylammonium bromide (CTAB) or dodecyl trimethylammonium bromide (DTAB)	Decreases the alkaline hydrolysis of curcumin	[52]
		Curcumin encapsulated in linolenic acid-modified copolymer micelles	Better carrier candidate for curcumin delivery	[53]
10	Microcapsule	Microcapsule fabricated by layer by layer assembly using poly(sodium 4-styrene sulfonic acid) and poly(ethylene imine) one after another	Suitable for drug delivery applications	[54]
		Bovine serum albumin gel microcapsule loaded with curcumin	Enhanced bioavailability, anti-tumour activity and anti-oxidant activity, etc.	[55]
11	Nanodisks	Curcumin entrapped nanodisks(disk-shaped phospholipid bilayersstabilized with apolipoproteins)	Improved delivery in in vitro cell culture	[56]
12	Yeast encapsulation	Curcumin encapsulated in Saccharomyces cerevisiae	Protected curcumin against oxidation environments, aided in slow and prolonged release and low degradation	[57]

Figure 2. Intravenous administration of nanoparticles. Nanoparticles attached with specific antibodies target the cells expressing the antigens and thereby, it could mediate the cell signaling.

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