Augmentation of therapeutic potential of curcumin using nanotechnology: current perspectives

References

• Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin: from kitchen to clinic”. Biochem Pharmacol. 2008;75:787–809.
   PubMed Web of Science ®Google Scholar
• Hatcher H, Planalp R, Cho J, et al. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65:1631–1652.
   PubMed Web of Science ®Google Scholar
• Manach C, Williamson G, Morand C, et al. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005;81:230s–242s.
   PubMed Web of Science ®Google Scholar
• Garcea G, Jones DJL, Singh R, et al. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer. 2004;90:1011–1015.
   PubMed Web of Science ®Google Scholar
• Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos. 1999;27:486–494.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–818.
   PubMed Web of Science ®Google Scholar
• Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453–470.
   PubMed Web of Science ®Google Scholar
• Leung MHM, Kee TW. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir. 2009;25:5773–5777.
   PubMed Web of Science ®Google Scholar
• Ernest H, Shetty R. Impact of nanotechnology on biomedical sciences: review of current concepts on convergence of nanotechnology with biology. Tissue Eng. 2005;18:19.
   Google Scholar
• Bogunia-Kubik K, Sugisaka M. From molecular biology to nanotechnology and nanomedicine. Biosystems. 2002;65:123–138.
   PubMed Web of Science ®Google Scholar
• Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009;3:16–20.
   PubMed Web of Science ®Google Scholar
• Pulavendran S, Rajam M, Rose C, et al. Hepatocyte growth factor incorporated chitosan nanoparticles differentiate murine bone marrow mesenchymal stem cell into hepatocytes in vitro. IET Nanobiotechnol. 2010;4:51–60.
   PubMed Web of Science ®Google Scholar
• Murugan R, Ramakrishna S. Nano-featured scaffolds for tissue engineering: a review of spinning methodologies. Tissue Eng. 2006;12:435–447.
   PubMedGoogle Scholar
• Gunasekera UA, Pankhurst QA, Douek M. Imaging applications of nanotechnology in cancer. Targ Oncol. 2009;4:169–181.
   PubMed Web of Science ®Google Scholar
• Kumar V, Lewis SA, Mutalik S, et al. Biodegradable microspheres of curcumin for treatment of inflammation. Indian J Physiol Pharmacol. 2002;46:209–217.
   PubMedGoogle Scholar
• Ma Z, Shayeganpour A, Brocks DR, et al. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed Chromatogr. 2007;21:546–552.
   PubMed Web of Science ®Google Scholar
• Narayanan NK, Nargi D, Randolph C, et al. Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. Int J Cancer. 2009;125:1–8.
   PubMed Web of Science ®Google Scholar
• Rahman SMH, Telny TC, Ravi TK, et al. Role of surfactant and pH in dissolution of curcumin. Indian J Pharm Sci. 2009;71:139–142.
   PubMed Web of Science ®Google Scholar
• Yoo SD, Lee SH, Kang E, et al. Bioavailability of itraconazole in rats and rabbits after administration of tablets containing solid dispersion particles. Drug Dev Ind Pharm. 2000;26:27–34.
   PubMed Web of Science ®Google Scholar
• Kaewnopparat N, Kaewnopparat S, Jangwang A, et al. Increased solubility, dissolution and physicochemical studies of curcumin-polyvinylpyrrolidone K-30 solid dispersions. World Acad Sci Eng Technol. 2009;31:229.
   Google Scholar
• Reddy PD, Swarnalatha D. Recent advances in novel drug delivery systems. Int J PharmTech Res. 2010;2:2025–2027.
   Google Scholar
• Yu H, Huang Q. Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch. Food Chem. 2010;119:669–674.
   Web of Science ®Google Scholar
• Tonnesen HH, Masson M, Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int J Pharm. 2002;244:127–135.
   PubMed Web of Science ®Google Scholar
• Iwunze MO. Binding and distribution characteristics of curcumin solubilized in CTAB micelle. J Mole Liq. 2004;111:161–165.
   Web of Science ®Google Scholar
• Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353–356.
   PubMed Web of Science ®Google Scholar
• Bano G, Raina RK, Zutshi U, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991;41:615–617.
   PubMed Web of Science ®Google Scholar
• Velpandian T, Jasuja R, Bhardwaj RK, et al. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet. 2001;26:241–247.
   PubMed Web of Science ®Google Scholar
• Liu ZJ, Han G, Yu JG, et al. Preparation and drug releasing property of curcumin nanoparticles. Zhong Yao Cai. 2009;32:277–279.
   PubMedGoogle Scholar
• Li L, Braiteh FS, Kurzrock R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005;104:1322–1331.
   PubMed Web of Science ®Google Scholar
• Lin CC, Lin HY, Chen HC, et al. Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions. Food Chem. 2009;116:923–928.
   Web of Science ®Google Scholar
• Liu A, Lou H, Zhao L, et al. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed Anal. 2006;40:720–727.
   PubMed Web of Science ®Google Scholar
• Shaikh J, Ankola DD, Beniwal V, et al. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci. 2009;37:223–230.
   PubMed Web of Science ®Google Scholar
• Wang X, Wang YW, Huang Q. Enhancing stability and oral bioavailability of polyphenols using nanoemulsions, in micro/nanoencapsulation of active food ingredients. Washington (DC): American Chemical Society; 2009. p. 198–212.
   Google Scholar
• Lopes-Rodrigues V, Sousa E, Vasconcelos MH. Curcumin as a modulator of p-glycoprotein in cancer: challenges and perspectives. Pharmaceuticals. 2016;9:71.
   Web of Science ®Google Scholar
• Song IS, Cha JS, Choi MK. Characterization, in vivo and in vitro evaluation of solid dispersion of curcumin containing d-alpha-tocopheryl polyethylene glycol 1000 succinate and mannitol. Molecules. 2016;21:1386.
   PubMed Web of Science ®Google Scholar
• Paradkar A, Ambike AA, Jadhav BK, et al. Characterization of curcumin-PVP solid dispersion obtained by spray drying. Int J Pharm. 2004;271:281–286.
   PubMed Web of Science ®Google Scholar
• Wang X, Jiang Y, Wang YW, et al. Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2008;108:419–424.
   PubMed Web of Science ®Google Scholar
• Hu L, Jia Y, Niu F, et al. Preparation and enhancement of oral bioavailability of curcumin using microemulsions vehicle. J Agric Food Chem. 2012;60:7137–7141.
   PubMed Web of Science ®Google Scholar
• Lin CC, Lin HY, Chi MH, et al. Preparation of curcumin microemulsions with food-grade soybean oil/lecithin and their cytotoxicity on the HepG2 cell line. Food Chem. 2014;154:282–290.
   PubMed Web of Science ®Google Scholar
• Zou L, Zheng B, Liu W, et al. Enhancing nutraceutical bioavailability using excipient emulsions: influence of lipid droplet size on solubility and bioaccessibility of powdered curcumin. J Funct Foods. 2015;15:72–83.
   Web of Science ®Google Scholar
• Krausz AE, Adler BL, Cabral V, et al. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 2015;11:195–206.
   PubMed Web of Science ®Google Scholar
• Reeves A, Vinogradov SV, Morrissey P, et al. Curcumin-encapsulating nanogels as an effective anticancer formulation for intracellular uptake. Mol Cell Pharmacol. 2015;7:25–40.
   PubMedGoogle Scholar
• Purpura M, Lowery RP, Wilson JM, et al. Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. Eur J Nutr. 2017 [Feb 16]. DOI:https://doi.org/10.1007/s00394-016-1376-9
   PubMed Web of Science ®Google Scholar
• Thangapazham RL, Puri A, Tele S, et al. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int J Oncol. 2008;32:1119–1123.
   PubMed Web of Science ®Google Scholar
• Saengkrit N, Saesoo S, Srinuanchai W, et al. Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy. Colloids Surf B Biointerfaces. 2014;114:349–356.
   PubMed Web of Science ®Google Scholar
• Dai F, Zhang X, Shen W, et al. Liposomal curcumin inhibits hypoxia-induced angiogenesis after transcatheter arterial embolization in VX2 rabbit liver tumors. Onco Targets Ther. 2015;8:2601–2611.
   PubMed Web of Science ®Google Scholar
• Nair KL, Thulasidasan AKT, Deepa G, et al. Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier. Int J Pharm. 2012;425:44–52.
   PubMed Web of Science ®Google Scholar
• Tran LD, Hoang NMT, Mai TT, et al. Nanosized magnetofluorescent Fe3O4–curcumin conjugate for multimodal monitoring and drug targeting. Colloids Surf A Physicochem Eng Asp. 2010;371:104–112.
   Web of Science ®Google Scholar
• Mancarella S, Greco V, Baldassarre F, et al. Polymer-coated magnetic nanoparticles for curcumin delivery to cancer cells. Macromol Biosci. 2015;15:1365–1374.
   PubMed Web of Science ®Google Scholar
• Yallapu MM, Othman SF, Curtis ET, et al. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. Int J Nanomedicine. 2012;7:1761–1779.
   PubMed Web of Science ®Google Scholar
• Lv L, Shen Y, Liu J, et al. Enhancing curcumin anticancer efficacy through di-block copolymer micelle encapsulation. J Biomed Nanotechnol. 2014;10:179–193.
   PubMed Web of Science ®Google Scholar
• Leung MHM, Colangelo H, Kee TW. Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis. Langmuir. 2008;24:5672–5675.
   PubMed Web of Science ®Google Scholar
• Song Z, Zhu W, Liu N, et al. Linolenic acid-modified PEG-PCL micelles for curcumin delivery. Int J Pharm. 2014;471:312–321.
   PubMed Web of Science ®Google Scholar
• Manju S, Sreenivasan K. Hollow microcapsules built by layer by layer assembly for the encapsulation and sustained release of curcumin. Colloids Surf B Biointerfaces. 2011;82:588–593.
   PubMed Web of Science ®Google Scholar
• Paşcalău V, Soritau O, Popa F, et al. Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules. J Biomater Appl. 2016;30:857–872.
   PubMed Web of Science ®Google Scholar
• Ghosh M, Singh ATK, Xu W, et al. Curcumin nanodisks: formulation and characterization. Nanomedicine. 2011;7:162–167.
   PubMed Web of Science ®Google Scholar
• Paramera EI, Konteles SJ, Karathanos VT. Stability and release properties of curcumin encapsulated in Saccharomyces cerevisiae, β-cyclodextrin and modified starch. Food Chem. 2011;125:913–922.
   Web of Science ®Google Scholar
• Salaün F, Vroman I. Curcumin-loaded nanocapsules: formulation and influence of the nanoencapsulation processes variables on the physico-chemical characteristics of the particles. Int J Chem React Eng. 2009;7:11–08.
   Web of Science ®Google Scholar
• Nam SH, Nam HY, Joo JR, et al. Curcumin-loaded PLGA nanoparticles coating onto metal stent by electrophoretic deposition techniques. Bull Korean Chem Soc. 2007;28:397.
   Web of Science ®Google Scholar
• Tsai YM, Chien CF, Lin LC, et al. Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration. Int J Pharm. 2011;416:331–338.
   PubMed Web of Science ®Google Scholar
• Zhao J, Liu J, Xu S, et al. Graft copolymer nanoparticles with pH and reduction dual-induced disassemblable property for enhanced intracellular curcumin release. ACS Appl Mater Interfaces. 2013;5:13216–13226.
   PubMed Web of Science ®Google Scholar
• Patra D, Sleem F. A new method for pH triggered curcumin release by applying poly(L-lysine) mediated nanoparticle-congregation. Anal Chim Acta. 2013;795:60–68.
   PubMed Web of Science ®Google Scholar
• Ma N, Ma C, Li C, et al. Influence of nanoparticle shape, size, and surface functionalization on cellular uptake. J Nanosci Nanotech. 2013;13:6485–6498.
   PubMed Web of Science ®Google Scholar
• Dandekar P, Dhumal R, Jain R, et al. Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies. Food Chem Toxicol. 2010;48:2073–2089.
   PubMed Web of Science ®Google Scholar
• Li X, Yuan H, Zhang C, et al. Preparation and in-vitro/in-vivo evaluation of curcumin nanosuspension with solubility enhancement. J Pharm Pharmacol. 2016;68:980–988.
   PubMed Web of Science ®Google Scholar
• Nirmala C, Anand S, Puvanakrishnan R. Curcumin treatment modulates collagen metabolism in isoproterenol induced myocardial necrosis in rats. Mol Cell Biochem. 1999;197:31–37.
   PubMed Web of Science ®Google Scholar
• Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mole Cell Biochem. 1996;159:85–93.
   PubMed Web of Science ®Google Scholar
• Manikandan P, Sumitra M, Aishwarya S, et al. Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int J Biochem Cell Biol. 2004;36:1967–1980.
   PubMed Web of Science ®Google Scholar
• Quiles JL, Aguilera C, Mesa MD, et al. An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits. Biofactors. 1998;8:51–57.
   PubMed Web of Science ®Google Scholar
• Sidhu GS, Singh AK, Thaloor D, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998;6:167–177.
   PubMedGoogle Scholar
• Jacob A, Wu R, Zhou M, et al. Mechanism of the anti-inflammatory effect of curcumin: PPAR-gamma activation. PPAR Res. 2007;2007:89369.
   PubMed Web of Science ®Google Scholar
• Jiang Y. Micro-and nano-encapsulation and controlled-release of phenolic compounds and other food ingredients. New Brunswick (NJ): Rutgers University-Graduate School-New Brunswick; 2009.
   Google Scholar
• Sou K, Inenaga S, Takeoka S, et al. Loading of curcumin into macrophages using lipid-based nanoparticles. Int J Pharm. 2008;352:287–293.
   PubMed Web of Science ®Google Scholar
• Ramshankar YV, Suresh S, Devi K. Novel self-emulsifying formulation of curcumin with improved dissolution, antiangiogenic and anti-inflammatory activity. Clin Res Regul Aff. 2008;25:213–234.
   Google Scholar
• Sindhu K, Indra R, Rajaram A, et al. Investigations on the interaction of gold-curcumin nanoparticles with human peripheral blood lymphocytes. J Biomed Nanotechnol. 2011;7:56.
   PubMed Web of Science ®Google Scholar
• Chaubey P, Patel RR, Mishra B. Development and optimization of curcumin-loaded mannosylated chitosan nanoparticles using response surface methodology in the treatment of visceral leishmaniasis. Expert Opin Drug Deliv. 2014;11:1163–1181.
   PubMed Web of Science ®Google Scholar
• Maiti K, Mukherjee K, Gantait A, et al. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int J Pharm. 2007;330:155–163.
   PubMed Web of Science ®Google Scholar
• Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34:660–665.
   PubMed Web of Science ®Google Scholar
• Mulik RS, Mo¨nkko¨nen J, Juvonen RO, et al. ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model. Mol Pharmaceutics. 2010;7:815–825.
   PubMed Web of Science ®Google Scholar
• Tiwari SK, Agarwal S, Tripathi A, et al. Bisphenol-A mediated inhibition of hippocampal neurogenesis attenuated by curcumin via canonical Wnt pathway. Mol Neurobiol. 2016;53:3010–3029.
   PubMed Web of Science ®Google Scholar
• Liu S, Cao Y, Qu M, et al. Curcumin protects against stroke and increases levels of Notch intracellular domain. Neurol Res. 2016;38:553–559.
   PubMed Web of Science ®Google Scholar
• Mourtas S, Canovi M, Zona C, et al. Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1–42 peptide. Biomaterials. 2011;32:1635–1645.
   PubMed Web of Science ®Google Scholar
• Ramalingam P, Ko YT. Enhanced oral delivery of curcumin from N-trimethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluations. Pharm Res. 2015;32:389–402.
   PubMed Web of Science ®Google Scholar
• Kundu P, Das M, Tripathy K, et al. Delivery of dual drug loaded lipid-based nanoparticles across the blood–brain barrier impart enhanced neuroprotection in a rotenone-induced mouse model of Parkinson’s disease. ACS Chem Neurosci. 2016;7:1658–1670.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang Y, Liu Q, et al. Rational design of multifunctional dendritic mesoporous silica nanoparticles to load curcumin and enhance efficacy for breast cancer therapy. ACS Appl Mater Interfaces. 2016;8:26511–26523.
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363–398.
   PubMed Web of Science ®Google Scholar
• López‐Lázaro M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res. 2008;52:S103–127.
   PubMed Web of Science ®Google Scholar
• Ma Z, Haddadi A, Molavi O, et al. Micelles of poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res. 2008;86A:300–310.
   Web of Science ®Google Scholar
• Sahu A, Kasoju N, Bora U. Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules. 2008;9:2905–2912.
   PubMed Web of Science ®Google Scholar
• Sahu A, Bora U, Kasoju N, et al. Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 2008;4:1752–1761.
   PubMed Web of Science ®Google Scholar
• Mukerjee A, Vishwanatha JK. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res. 2009;29:3867–3875.
   PubMed Web of Science ®Google Scholar
• Prajakta D, Ratnesh J, Chandan K, et al. Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer. J Biomed Nanotechnol. 2009;5:445–455.
   PubMed Web of Science ®Google Scholar
• Yallapu MM, Maher DM, Sundram V, et al. Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res. 2010;3:11.
   PubMed Web of Science ®Google Scholar
• Rossi JJ. Receptor-targeted siRNAs. Nat Biotechnol. 2005;23:682–684.
   PubMed Web of Science ®Google Scholar
• Ganta S, Amiji M. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharmaceutics. 2009;6:928–939.
   PubMed Web of Science ®Google Scholar
• Bisht S, Feldmann G, Soni S, et al. Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapy. J Nanobiotechnol. 2007;5:3.
   PubMedGoogle Scholar
• Gupta V, Aseh A, Ríos CN, et al. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int J Nanomedicine. 2009;4:115–122.
   PubMed Web of Science ®Google Scholar
• Sun M, Gao Y, Guo C, et al. Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle. J Nanopart Res. 2010;12:3111–3122.
   Web of Science ®Google Scholar
• van de Luijtgaarden W, Guha S, Milano F, et al. Nano-curcumin as a promising new therapy for treatment of esophageal adenocarcinoma. Gastroenterology. 2011;140:S–223–S-224.
   Web of Science ®Google Scholar
• Klippstein R, Wang JTW, El-Gogary RI, et al. Passively targeted curcumin-loaded PEGylated PLGA nanocapsules for colon cancer therapy in vivo. Small. 2015;11:4704–4722.
   PubMed Web of Science ®Google Scholar
• Anitha A, Sreeranganathan M, Chennazhi KP, et al. In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies. Eur J Pharm Biopharm. 2014;88:238–251.
   PubMed Web of Science ®Google Scholar
• Popat A, Karmakar S, Jambhrunkar S, et al. Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids Surf B Biointerfaces. 2014;117:520–527.
   PubMed Web of Science ®Google Scholar
• Rao W, Zhang W, Poventud-Fuentes I, et al. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomater. 2014;10:831–842.
   PubMed Web of Science ®Google Scholar
• Tima S, Okonogi S, Ampasavate C, et al. Development and characterization of FLT3-specific curcumin-loaded polymeric micelles as a drug delivery system for treating FLT3-overexpressing leukemic cells. J Pharm Sci. 2016;105:3645–3657.
   PubMed Web of Science ®Google Scholar
• Anand P, Thomas SG, Kunnumakkara AB, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol. 2008;76:1590–1611.
   PubMed Web of Science ®Google Scholar
• Markatou E, Gionis V, Chryssikos GD, et al. Molecular interactions between dimethoxycurcumin and Pamam dendrimer carriers. Int J Pharm. 2007;339:231–236.
   PubMed Web of Science ®Google Scholar
• Basile V, Ferrari E, Lazzari S, et al. Curcumin derivatives: molecular basis of their anti-cancer activity. Biochem Pharmacol. 2009;78:1305–1315.
   PubMed Web of Science ®Google Scholar
• Adams BK, Ferstl EM, Davis MC, et al. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg Med Chem. 2004;12:3871–3883.
   PubMed Web of Science ®Google Scholar
• Furness MS, Robinson TP, Ehlers T, et al. Antiangiogenic agents: studies on fumagillin and curcumin analogs. Curr Pharm Des. 2005;11:357–373.
   PubMed Web of Science ®Google Scholar
• Ohori H, Yamakoshi H, Tomizawa M, et al. Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther. 2006;5:2563–2571.
   PubMed Web of Science ®Google Scholar
• Anuradha C, Aukunuru J. Preparation, characterisation and in vivo evaluation of bis-demethoxy curcumin analogue (BDMCA) nanoparticles. Trop J Pharm Res. 2010;9:51–58.
   Web of Science ®Google Scholar
• Subramanian SB, Francis AP, Devasena T. Chitosan-starch nanocomposite particles as a drug carrier for the delivery of bis-desmethoxy curcumin analog. Carbohydr Polym. 2014;114:170–178.
   PubMed Web of Science ®Google Scholar
• Kesharwani P, Banerjee S, Padhye S, et al. Parenterally administrable nano-micelles of 3,4-difluorobenzylidene curcumin for treating pancreatic cancer. Colloids Surf B Biointerfaces. 2015;132:138–145.
   PubMed Web of Science ®Google Scholar
• Qiu C, Hu Y, Wu K, et al. Synthesis and biological evaluation of allylated mono-carbonyl analogues of curcumin (MACs) as anti-cancer agents for cholangiocarcinoma. Bioorg Med Chem Lett. 2016;26:5971–5976.
   PubMed Web of Science ®Google Scholar
• Misra R, Sahoo SK. Coformulation of doxorubicin and curcumin in poly(d,l-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharmaceutics. 2011;8:852–866.
   PubMed Web of Science ®Google Scholar
• Duan J, Mansour HM, Zhang Y, et al. Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm. 2012;426:193–201.
   PubMed Web of Science ®Google Scholar
• Zhao X, Chen Q, Li Y, et al. Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. Eur J Pharm Biopharm. 2015;93:27–36.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Wilkinson J, Christine Pietsch E, et al. Iron chelation in the biological activity of curcumin. Free Radic Biol Med. 2006;40:1152–1160.
   PubMed Web of Science ®Google Scholar
• Jiao Y, Wilkinson J, Di X, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2008;113:462–469.
   PubMed Web of Science ®Google Scholar
• Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21:2895–2900.
   PubMed Web of Science ®Google Scholar
• Burgos-Moron, E, Calderón-Montaño JM, Salvador J, et al. The dark side of curcumin. Int J Cancer. 2010;126(7):1771–1775.
   PubMed Web of Science ®Google Scholar
• Canamares MV, Garcia-Ramos JV, Sanchez-Cortes S. Degradation of curcumin dye in aqueous solution and on ag nanoparticles studied by ultraviolet-visible absorption and surface-enhanced Raman spectroscopy. Appl Spectrosc. 2006;60:1386–1391.
   PubMed Web of Science ®Google Scholar