Figures & data
![](/cms/asset/e6a9bfc0-b1b8-4d0b-a7f2-b6d742332c6d/ianb_a_1557670_uf0001_c.jpg)
Scheme 1. Schematic representation of the synthesis route of the SPIONs. (a) ammonia addition, (b) iron oxide nanoparticles formation, (c) separation and washing with permanent magnet.
![Scheme 1. Schematic representation of the synthesis route of the SPIONs. (a) ammonia addition, (b) iron oxide nanoparticles formation, (c) separation and washing with permanent magnet.](/cms/asset/34e95c53-dd2f-42bd-9084-044571e92a89/ianb_a_1557670_sch0001_c.jpg)
Scheme 2. Schematic representation of the synthesis route of the FA-mPEG-PAMAM G3-CUR@SPIONs. (Carboxylic acid group of folic acid reacts with the primary amine end groups of dendrimer).
![Scheme 2. Schematic representation of the synthesis route of the FA-mPEG-PAMAM G3-CUR@SPIONs. (Carboxylic acid group of folic acid reacts with the primary amine end groups of dendrimer).](/cms/asset/6ac5a086-4283-442a-86cb-6fa860acf86b/ianb_a_1557670_sch0002_c.jpg)
Figure 2. (a, b) TEM micrograph and corresponding size distribution histogram of the synthesized nanocomplex. (c) Hydrodynamic size distribution of the nanocomplex obtained by DLS analysis.
![Figure 2. (a, b) TEM micrograph and corresponding size distribution histogram of the synthesized nanocomplex. (c) Hydrodynamic size distribution of the nanocomplex obtained by DLS analysis.](/cms/asset/18f60bdb-092b-42b2-8d41-28d74ddbe712/ianb_a_1557670_f0002_b.jpg)
Figure 4. UV-vis spectra show the surface plasmon resonance of curcumin (purple line), dendrimer nanoparticles without drug (orange line) and dendrimer nanoparticles with drug (green line).
![Figure 4. UV-vis spectra show the surface plasmon resonance of curcumin (purple line), dendrimer nanoparticles without drug (orange line) and dendrimer nanoparticles with drug (green line).](/cms/asset/01b22295-2511-478d-8d30-c8ab949a0574/ianb_a_1557670_f0004_c.jpg)
Figure 5. FTIR spectra of folic acid (a); FTIR spectra of curcumin-dendrimer nanocomplex (b); FTIR spectra of folic acid-curcumin-dendrimer nanocomplex (c).
![Figure 5. FTIR spectra of folic acid (a); FTIR spectra of curcumin-dendrimer nanocomplex (b); FTIR spectra of folic acid-curcumin-dendrimer nanocomplex (c).](/cms/asset/f8c623e9-06de-4b6a-aef7-b60fa985cc64/ianb_a_1557670_f0005_b.jpg)
Figure 6. The in vitro release profile of the encapsulated curcumin from the nanocomplex versus free-from curcumin.
![Figure 6. The in vitro release profile of the encapsulated curcumin from the nanocomplex versus free-from curcumin.](/cms/asset/f352eb07-26e3-4a7a-8b5a-69b85489566e/ianb_a_1557670_f0006_c.jpg)
Figure 7. The viability of KB and MCF-7 cells incubated with different concentrations of the nanocomplex for 12 h.
![Figure 7. The viability of KB and MCF-7 cells incubated with different concentrations of the nanocomplex for 12 h.](/cms/asset/62fbc593-9ec6-44ca-9731-e00c83e5559a/ianb_a_1557670_f0007_c.jpg)