Figures & data
Figure 1. Expression of miR-193b and IGF1R in renal cell carcinoma. (A) Expression of miR-193b in renal cancer tissues and paracancerous tissues; (B) expression of IGF1R in renal cancer tissues and paracancerous tissues; (C) expression of miR-193b in renal cancer cells and renal tubular epithelial cells; *p < .05.
Figure 2. Overexpression of miR-193b inhibits proliferation, migration and invasion of renal cancer cells. (A) The effect of over-expression of miR-193b on the expression of miR-193b in CaKi-1 cells; (B) the effect of over-expression of miR-193b on the activity of CaKi-1 cells; (C,D) the effect of over-expression of miR-193b on the migration and invasion of Ki-1 cells; *p < .05.
Figure 3. Knockdown IGF1R inhibits proliferation, migration and invasion of Caki-1 cells. (A)The effect of knocking down IGF1R on the expression of IGF1R in CaKi-1 cells; (B) the effect of knocking down IGF1R on the activity of CaKi-1 cells; (C) the effect of knocking down IGF1R on the migration and invasion of CaKi-1 cells; *p < .05.
Figure 4. miR-193 targets IGF1R. (A) MiR-193 targeting combined with sequence information of IGF1R gene 3'UTR; (B) MiR-193b targeting on luciferase activity in CaKi-1 cells; (C) MiR-193b targeting on the expression of IGF1R in CaKi-1 cells; (D) MiR-193b targeting on the expression of IGF1R protein in CaKi-1 cells; compared with the group of MiR-con, *p < .05, compared with the group of anti-MiR-con, #p < .05.
Figure 5. Overexpression of IGF1R partially reverses the inhibitory effect of miR-193b on proliferation, migration and invasion of Caki-1 cells. (A) The effect of overexpression of IGF1R on the expression of IGF1R in CaKi-1 cells; (B) The effect of overexpression of IGF1R on the activity of CaKi-1 cells; (C) The effect of overexpression of IGF1R on the migration and invasion of Ki-1 cells; Compared with the MiR-con group, *p < .05; Compared with the MiR-193b + Ctrl group, #p < .05.
Figure 6. Effect of overexpression of miR-193b on tumourigenic ability of nude mice. (A) The effect of over-expression of miR-193b on the tumourigenic volume of nude mice; (B) the effect of over-expression of miR-193b on the tumourigenic weight of nude mice; (C) the expression of miR-193b in tumourigenic tissue of nude mice; (D) the expression of IGF1R protein in tumourigenic tissue of nude mice; *p < .05.
