Figures & data
Table 1. Immunization study design.
Figure 1. Schematic diagram of the experimental procedure. The schematic diagram represents the synthesis of N-trimethyl chitosan nanoparticles (N-TMC NPs), Bordetella pertussis antigen loading, intranasal administration, and immunization study carried out in this work.
![Figure 1. Schematic diagram of the experimental procedure. The schematic diagram represents the synthesis of N-trimethyl chitosan nanoparticles (N-TMC NPs), Bordetella pertussis antigen loading, intranasal administration, and immunization study carried out in this work.](/cms/asset/82a33cae-71e9-4b66-8727-3fccb8d53f0d/ianb_a_1629948_f0001_c.jpg)
Figure 2. Transmission electron microscopy micrograph of PTd + FHA-loaded TMC NPs. PTd: pertussis toxoid; FHA: Filamentous hemagglutinin; TMC: N-trimethyl chitosan; NP: nanoparticle.
![Figure 2. Transmission electron microscopy micrograph of PTd + FHA-loaded TMC NPs. PTd: pertussis toxoid; FHA: Filamentous hemagglutinin; TMC: N-trimethyl chitosan; NP: nanoparticle.](/cms/asset/143f24ff-e4b1-43cd-b716-f2cbcaf25565/ianb_a_1629948_f0002_b.jpg)
Figure 3. In vitro release profile of antigen from TMC NPs. TMC: N-trimethyl chitosan; NP: nanoparticle.
![Figure 3. In vitro release profile of antigen from TMC NPs. TMC: N-trimethyl chitosan; NP: nanoparticle.](/cms/asset/ad1c270d-b3c0-4b73-bc59-a064622c9e75/ianb_a_1629948_f0003_c.jpg)
Table 2. Characterization of antigen-loaded TMC NPs.