The expression level and clinical significance of lncRNA X91348 in hepatocellular carcinoma

Figures & data

Figure 1. Relative expression of X91348 in tissues samples. X91348 expression level was significantly lower in HCC tissues than in adjacent non-cancerous tissues (p< .05).

Figure 2. Relative expression of X91348 in serum samples. Serum X91348 expression level was significantly decreased in patients with HCC compared with healthy controls (p< .05).

Table 1. The relationship between clinicopathologic characteristics and X91348 expression.

Clinicopathologic characteristics	n	X91348 expression		χ^2	p Value
		High	Low
Age				1.206	.272
≤50	44	25	19	–	–
>50	63	29	34	–	–
Gender				0.777	.378
Female	49	27	22	–	–
Male	58	27	31	–	–
Tumour size				26.615	<.001
<3 cm	18	14	4	–	–
3–5 cm	29	21	8	–	–
5–10 cm	31	15	16	–	–
>10 cm	29	4	25	–	–
Tumour site				2.192	.334
Left	45	26	19	–	–
Right	39	19	20	–	–
Both	23	9	14	–	–
HBsAg				10.543	.001
No	45	31	14	–	–
Yes	63	23	39	–	–
AFP				4.525	.210
<20 ng/mL	8	1	7	–	–
20–400 ng/mL	15	10	5	–	–
>400–1000 ng/mL	37	16	21	–	–
>1000 ng/mL	47	27	20	–	–
Portal vein tumour thrombus				1.829	.176
No	37	22	15	–	–
Yes	70	32	38	–	–
Child-Pugh				21.956	<.001
A	14	11	3	–	–
B	57	36	21	–	–
C	36	7	29	–	–
Therapies				4.918	.086
TAGE	30	11	19
Conservative treatment	48	24	24	–	–
Combined therapy	29	19	10	–	–
Neoplasm metastasis				0.075	.784
Co	37	18	19	–	–
Yes	70	36	34	–	–

Figure 3. ROC curve estimating diagnostic value of X91348 expression. The AUC reached 0.807 while the sensitivity and specificity were 82 and 75.4%, respectively.

Figure 4. Kaplan–Meier analysis for overall survival of patients with HCC stratified by the expression of X91348. Patients with high X91348 expression lived longer than those with low X91348 expression (Log rank test, p< .001).

Table 2. Cox regression analysis adjusting for clinical factors to estimate prognostic value of X91348 in HCC.

Parameter	Risk ratio	95 % confidence interval	p Value
Neoplasm metastasis	3.125	1.200–8.137	.020
High-X91348 expression	–	–	–
Low-X91348 expression	5.527	1.791–17.057	.003